青岛大学学报（医学版）2024，Vol.60Issue(2)：243-246,4.DOI:10.11712/jms.2096-5532.2024.60.057
艾司氯胺酮联合布托啡诺对老年病人全髋关节置换术后镇痛效果及早期康复的影响
Effect of esketamine combined with butorphanol on analgesic effect and early rehabilitation in elderly patients after total hip arthroplas-ty
摘要
Abstract
Objective To investigatethe effect of esketamine combined with butorphanol on patient-controlled intravenous analgesia(PCIA)and early rehabilitationin elderly patients aftertotal hiparthroplasty.Methods A total of 85 elderly patients who underwent total hip arthroplasty under combined spinal-epidural anesthesia in our hospital from January 2022 to March 2023 were enrolled and randomly divided into experimental group with 43 patients and control group with 42 patients.The patients in the control group received butorphanol 0.15 mg/kg alone for postoperative PCIA,and those in the experimental group received butor-phanol 0.10 mg/kg combined with esketamine 100 mg for postoperative PCIA.The Visual Analogue Scale(VAS)score for pain and Ramsay sedation score were recorded at 6,24,and 48 h after surgery;the 15-item Quality of Recovery(QoR-15)scale was used to evaluate the status of early recovery at 24 and 48 h after surgery;postoperative adverse reactions were also recorded.Results Compared with the control group,the observation group had significantly lower VAS score and Ramsay sedation score at 6,24,and 48 h after surgery(Z=2.167-5.845,P＜0.05)and a significantly higher QoR-15 score at 24 and 48 h after surgery(Z=3.773,6.085,P＜0.05).There was no significant difference in the overallincidence rate of adverse reactions between the two groups(P＞0.05).Conclusion The combination of esketamine and butorphanol for postoperative PCIA can effectively improve analgesic effect and sedation level after surgery and promote early postoperative recovery in elderly patients undergoing total hip ar-throplasty.关键词
氯胺酮/布托啡诺/疼痛,手术后/镇痛,病人控制/康复Key words
ketamine/butorphanol/pain,postoperative/analgesia,patient-controlled/rehabilitation分类
医药卫生引用本文复制引用
曹蕾,刘猛,王额尔敦..艾司氯胺酮联合布托啡诺对老年病人全髋关节置换术后镇痛效果及早期康复的影响[J].青岛大学学报（医学版）,2024,60(2):243-246,4.基金项目
山东省自然科学基金项目(ZR2020QH356) （ZR2020QH356）
军队卫勤保障能力创新与生成专项计划(21WQ019) （21WQ019）
