青岛大学学报（医学版）2024，Vol.60Issue(2)：247-251,5.DOI:10.11712/jms.2096-5532.2024.60.063
消化道颗粒细胞瘤临床特征分析
Clinical features of gastrointestinal granular cell tumor:an analysis of 22 cases
摘要
Abstract
Objective To investigatethe clinical features of gastrointestinal granular cell tumor(GCT),and to improve the understanding and clinical diagnosis and treatment of gastrointestinal GCT.Methods A retrospective analysis was performed for the clinical data of 22 patients with pathologically confirmed gastrointestinal GCT.Results Among the 22 patients,there were 17 male patients and 5 female patients,with a mean age of(49.36±8.45)years,and the lesion sites were the esophagus in 17 pa-tients(77.27％),the ileocecusin 2 patients(9.09％),and the colon in 3 patients(13.64％).All patients presented with nonspecific gastrointestinal symptoms,and the maximum diameter of endoscopic lesions showed a range of 0.29-2.00 cm.All 22 patients un-derwent CT examination,among whom 6 had slight thickening of the wall of the esophagus and 1 had slight thickening of the wall of the cecum,and no obvious abnormality was observed for the other 15 patients.One patient underwent PET-CT,and the results showed mild thickening of the lower esophagus,with nodular metabolic hyperintensities and a SUVmax value of about 2.1.All 22 patients underwent endoscopic examination,among whom 15(68.18％)had yellow lesions and 7(31.82％)had white lesions.Endo-scopic ultrasound(EUS)was performed for 13 patients,among whom 7(53.84％)had lesions originating from the submucosal la-yer,5(38.46％)had lesions originating from the muscularis mucosa,and 1(7.70％)had lesions originating from the muscularis propria;12 patients(92.30％)had hypoechoic lesions,and 1 patient(7.70％)had hypoechoic lesions mixed with a small amount of hyperechoic changes;10 patients(76.92％)had even echo,and 3(23.08％)had uneven echo.Immunohistochemistry showed the expression of S100 in all lesions and the expression of CD68,SOX10,Ki-67,SDHB,and CD34 in some lesions.Of all 22 patients,20 received endoscopic treatment,1 received surgical treatment,and 1 was followed up.The patients were followed up for 7-69 months,with a median follow-up time of 23 months;1 patient was lost to follow-up after chemotherapy,while the other pa-tients had no tumor recurrence ormetastasis.Conclusion Gastrointestinal GCT is commonly seen in male individuals,with a lack of specific clinical symptoms.The combination of endoscopy and EUS can improve the diagnostic rate of gastrointestinal GCT,and pathology and immunohistochemistry are required to make a con-firmed diagnosis.Endoscopic treatment is currently a safe and effec-tive treatment method.关键词
颗粒细胞瘤/临床表现/腔内超声检查/病理状态,体征和症状Key words
granular cell tumor/clinical manifestations/en-dosonography/pathological conditions,signs and symptoms分类
医药卫生引用本文复制引用
张晓静,赵文君,孟品,刘爱玲,徐楠,徐永红..消化道颗粒细胞瘤临床特征分析[J].青岛大学学报（医学版）,2024,60(2):247-251,5.基金项目
山东省自然科学基金青年科学基金项目(Z-R2020QH031) （Z-R2020QH031）
