青岛大学学报（医学版）2024，Vol.60Issue(2)：313-316,4.DOI:10.11712/jms.2096-5532.2024.60.052
Sirt6在肾脏病中的研究进展
Research advances in Sirt6 in kidney disease
摘要
Abstract
The Sirtuins protein family is an evolutionarily conserved NAD+-dependent histone deacetylase family.Sirt6,as an important member of the Sirtuins family,is widely distributed in glomerular podocytes and renal tubular cells and exerts a renal protective effect through various pathways such as maintaining the homeostasis of podocytes and mitochondria and inhibiting in-flammation and fibrosis.This article reviews the structure of sirt6 and its role and mechanism in various renal diseases including di-abetic kidney disease,acute kidney injury,and hypertensive nephropathy,so as to provide a new target for the diagnosis and treat-ment of renal diseases.关键词
抗衰老酶/Sirt6/肾疾病/综述Key words
sirtuins/Sirt6/kidney diseases/review分类
医药卫生引用本文复制引用
魏玉娇,陈超,李明慧,徐晓燕,邱蕊,马瑞霞..Sirt6在肾脏病中的研究进展[J].青岛大学学报（医学版）,2024,60(2):313-316,4.基金项目
青岛市公共领域科技支撑计划项目(2012-1-3-2-(2)-nsh) （2012-1-3-2-(2）
青岛大学医学部"临床+X"工程科研项目(RZ-1900003244) （RZ-1900003244）
