日用化学品科学2024，Vol.47Issue(6)：13-18,6.DOI:10.3969/j.issn.1006-7264.2024.06.003
传明酸多肽组合物改善线粒体功能及炎性色沉的研究
Study on the improvement of mitochondrial function and inflammatory pigmentation by a translucent acid peptide composition
王琪 1郑含含 2张肖 2黄琳 2王晓东 1卢云宇2
作者信息
- 1. 上海优斐斯生物科技有限公司,上海 201403
- 2. 杭州彗柏生物科技有限公司,浙江 杭州 311200
- 折叠
摘要
Abstract
Four cell models were used to study the metabolic activity and mitochondrial morphology on human skin fibroblasts(HFF-1)of tranexamic acid alone and the combination of tranexamic acid+arginine/lysine peptide+glutathione(TXATidePro™),as well as the effects on ATP production,mtDNA copy number and autophagy levels in human keratinocytes(HaCaT),the effects on TNF-α and IL-1β levels in RAW264.7 cells,and the effects on the melanin levels in B16F10 cells.The results show that compared with the control group and tranexamic acid alone,the TXATidePro™ composition significantly promotes cell metabolic activity,improves mitochondrial quality,increases ATP production,reduces mtDNA damage,promotes autophagy,inhibits TNF-α and IL-1β,and reduces melanin content.It is confirmed that the TXATidePro™ composition can achieve anti-inflammation,brightening blemishes and resisting inflammatory pigmentation by improving the mitochondrial and autophagy functions of the skin cells.关键词
传明酸/精氨酸/赖氨酸多肽/谷胱甘肽/线粒体/mtDNA/细胞自噬/炎性色沉/黑色素Key words
tranexamic acid/arginine/lysine polypeptide/glutathione/mitochondria/mtDNA/autophagy/inflammatory pigmentation/melanin分类
化学化工引用本文复制引用
王琪,郑含含,张肖,黄琳,王晓东,卢云宇..传明酸多肽组合物改善线粒体功能及炎性色沉的研究[J].日用化学品科学,2024,47(6):13-18,6.
