日用化学品科学2024，Vol.47Issue(6)：64-69,6.DOI:10.3969/j.issn.1006-7264.2024.06.013
植物提取物组方基于3D皮肤模型的功效研究
Research on the efficacy of plant extract formulation based on 3D skin models
刘敏 1蒋玲玲 1孙翠 1叶磊 1郑久炎1
作者信息
- 1. 苏州蜜思肤化妆品股份有限公司,江苏 苏州 215200
- 折叠
摘要
Abstract
The seven plant extracts were crushed,extracted,decolorized,desalted,concentrated,and then added with pentanediol,1,2-hexanediol,glycerol,and trehalose to prepare the plant extract formulation(hereinafter referred to as the"formulation")in a certain proportion.Cytotoxic studies of the prepared formulation were carried out based on keratinocytes to determine the safe dosing concentration of the formulation.A 3D epidermal skin model(hereinafter referred to as 3D skin model)was constructed based on Chinese keratinocytes to study the effect of formulation on the change of water content in the stratum corneum.The 3D injured skin model was constructed with sodium lauryl sulfate(SLS)stimulation to study the effect of the formulation on pro-inflammatory factors(IL-1α)and inflammatory mediators(PGE2)content changes.The 3D injured skin model was constructed by capsaicin(CAP)stimulation to study the effect of formulation on the content of capsaicin receptor protein(TRPV1).And the soothing effect of the formulation was studied by hyaluronidase inhibition experiment.The experimental results indicated that the formulation,at certain concentrations,exhibited significant inhibitory effects on IL-1α,PGE2,TRPV1 and hyaluronidase,and can also significantly increase the water content of the stratum corneum.These findings suggest that the formulation possesses moisturizing,soothing and reparing effects,making it suitable to use in cosmetics with the corresponding claims.关键词
植物提取物/舒缓/抗敏/保湿/修护Key words
plant extract/soothing/anti-allergy/moisturizing/repair分类
化学化工引用本文复制引用
刘敏,蒋玲玲,孙翠,叶磊,郑久炎..植物提取物组方基于3D皮肤模型的功效研究[J].日用化学品科学,2024,47(6):64-69,6.
