四川医学2024，Vol.45Issue(5)：474-480,7.DOI:10.16252/j.cnki.issn1004-0501-2024.05.004
TWIST2、SNAI1、TPX2及Aurora-A表达水平与喉鳞癌患者预后的相关性
Correlation Between Expression Levels of TWIST2,SNAI1,TPX2,Aurora-A and the Prognosis of Laryngeal Squa-mous Cell Carcinoma
摘要
Abstract
Objective To analyze correlation between TWIST2,SNAI1,TPX2 and Aurora-A expression and prognosis of laryngeal squamous cell carcinoma patients.Methods From January 2016 to December 2020,103 patients with laryngeal squa-mous cell carcinoma diagnosed and treated in our hospital were included.Blood TPX2 were detected before surgery,and tumor tis-sues were collected during surgery to detect TWIST2,SNAI1 and Aurora-A expression in tumor tissues.According to 2-year fol-low-up results,patients were divided into good prognosis group(n=71)and poor prognosis group(n=29).General data and labo-ratory indicators of patients in two groups were compared and analyzed.Receiver operating(ROC)curve was drawn and used to e-valuate the diagnostic value of influencing factors in predicting patients'prognosis.Results The age,tumor stageⅣ,poorly differ-entiated to undifferentiated,SNAI1,Aurora-A and TPX2 expression of patients in good prognosis group were significantly lower than those in poor prognosis group,while TWIST2 was significantly higher than that in poor prognosis group(all P<0.05).CoX analy-sis showed that high SNAI1,Aurora-A and TPX2 was an independent risk factor for the prognosis of patients,while high TWIST2 expression was an independent protective factor for the prognosis.Patients were stratified according to treatment regimens and sur-gical methods,and effects of TWIST2,SNAI1,TPX2 and Aurora-A levels on the prognosis were also statistically significant(all P<0.05).After1-year follow-up,ROC curve showed that diagnostic efficacy of the combination of TWIST2,SNAI1,Aurora-A,and TPX2 expression levels in predicting the prognosis of patients was not statistically significant compared with that of TWIST2,SNAI1,Aurora-A,and TPX2 alone(all P<0.05),sensitivity of TWIST2,SNAI1,Aurora-A and TPX2 expression combined to pre-dict the prognosis of patients was 100.0%,and the specificity was 91.6%.During follow-up of 2 years,ROC curve showed that di-agnostic efficacy of the combination of TWIST2,SNAI1,Aurora-A,and TPX2 expression in predicting the prognosis of patients was significantly higher than that of TWIST2,SNAI1,Aurora-A,and TPX2 alone(all P<0.05),the sensitivity of TWIST2,SNAI1,Au-rora-A and TPX2 expression combined to predict the prognosis of patients was 93.1%,and the specificity was 87.3%.Conclusion TWIST2,SNAI1,Aurora-A and TPX2 combined diagnosis could effectively predict prognosis of patients with high specificity and sensitivity.关键词
生物标志物/喉鳞癌/预后/相关性分析Key words
biological marker/laryngeal squamous carcinoma/prognosis/correlation analysis分类
医药卫生引用本文复制引用
杨文婧,郭珊珊,许丽萍,陶倩,王欢,王书谦..TWIST2、SNAI1、TPX2及Aurora-A表达水平与喉鳞癌患者预后的相关性[J].四川医学,2024,45(5):474-480,7.基金项目
2021年度河北省医学科学研究计划项目(编号:20211073) （编号:20211073）
