四川医学2024，Vol.45Issue(5)：486-490,5.DOI:10.16252/j.cnki.issn1004-0501-2024.05.006
高龄对妊娠期糖尿病患者孕中期叶酸、维生素B12水平的影响
Effect of Advanced Mature Age on Folate and Vitamin B12 During the Second Trimesters of Gestation in Patients with Gestational Diabetes Mellitus
摘要
Abstract
Objective To investigate the effects of advanced mature age on serum folate and vitamin B12 during the sec-ond trimesters of gestation in patients with gestational diabetes mellitus(GDM),and the relationship with pregnancy outcomes,with a view to providing better clinical diagnosis,treatment and health care guidance for GDM patients with advanced age.Methods From January 2021 to July 2022,212 GDM patients who were transferred to our hospital for obstetric examination and delivery from designated community hospitals were selected,including 75 patients in the advanced-age GDM group(≥35 years old)and 137 pa-tients in the age-appropriate GDM group(<35 years old).The mid-pregnancy serum folate and vitamin B12 were compared,and their correlation with neonatal birth weight and other pregnancy outcomes were analyzed.Results Serum vitamin B12 during the second trimesters of gestation in the advanced-age GDM group were significantly lower than those in the age-appropriate GDM group[(232.04±65.79)pmol/L vs.(257.62±92.86)pmol/L,P<0.05].No differences were found in serum folic acid and fo-lic acid/Vit B12 ratios between two groups.And the number of weeks of delivery in the advanced-age GDM group was significantly lower than that in the age-appropriate GDM group[(38.57±1.32)w vs.(38.95±1.32)w,P<0.05]and neonatal weight[(3306.33±441.01)g vs.(3429.82±426.47)g,P<0.05]were lower than those of the age-appropriate group.The present study did not find any significant correlation between folic acid,vitamin B12,and folic acid/Vit B12 and the birth weight of neo-nates in GDM patients.Conclusion Vitamin B12 deficiency during the second trimesters of gestation would be more pronounced in the advanced-age GDM patients,and the newborns delivered by them had lower body weights,but no significant correlation was found.关键词
高龄妊娠/妊娠期糖尿病/叶酸/维生素B12Key words
advanced mature pregnancy/gestational diabetes mellitus/folate/vitamin B12分类
医药卫生引用本文复制引用
石敏,倪爱华,杨沐怿,王雅萍,雷磊..高龄对妊娠期糖尿病患者孕中期叶酸、维生素B12水平的影响[J].四川医学,2024,45(5):486-490,5.基金项目
江苏省妇幼健康科研项目(编号:F202128) （编号:F202128）
