四川医学2024，Vol.45Issue(5)：507-511,5.DOI:10.16252/j.cnki.issn1004-0501-2024.05.010
血清CF-6、HSP-70表达对慢性心力衰竭患者病情及预后的评估价值
The Evaluation Value of Serum CF-6 and HSP-70 Expression for the Condition and Prognosis of Patients with Chronic Heart Failure
李雅兰 1喻洪1
作者信息
- 1. 绵阳市中心医院心血管内科,四川 绵阳 621000
- 折叠
摘要
Abstract
Objective To investigate the value of serum mitochondrial coupling factor 6(CF-6)and heat shock protein 70(HSP-70)expression in evaluating the condition and prognosis of patients with chronic heart failure(CHF).Methods A total of 106 CHF patients admitted to our hospital from December 2020 to December 2021 were regarded as the CHF group,according to the New York Heart Association(NYHA)cardiac function grading standards,36 cases of NYHA grade Ⅱ were classified as the grade Ⅱ group,38 cases of NYHA gradeⅢ were classified as the gradeⅢ group,and 32 cases of NYHA gradeⅣ were classi-fied as the gradeⅣgroup;according to the prognosis,54 cases were included into a good prognosis group and 52 cases into a poor prognosis group;106 healthy volunteers who underwent physical examination during the same period in our hospital were regarded as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of CF-6 and HSP-70 in serum;multivariate Logistic regression was applied to analyze the risk factors affecting the prognosis of CHF;and receiver oper-ating characteristic(ROC)curve was applied to analyze the prognostic value of CF-6 and HSP-70 in serum for CHF.Results The expression levels of CF-6 and HSP-70 in the serum of the CHF group were obviously increased compared to the control group(P<0.05).The expression levels of CF-6 and HSP-70 in serum of patients with CHF in grade Ⅳ group were obviously higher than those in grade Ⅱ and Ⅲ groups,and the expression levels in grade Ⅲ group were obviously higher than those in gradeⅡ group(P<0.05).Compared with the good prognosis group,the levels of CF-6 and HSP-70 in the poor prognosis group were obviously increased(P<0.05).Serum creatinine level in poor prognosis group was significantly higher than that in good prognosis group(P<0.05).Multivariate Logistic regression analysis showed that CF-6,HSP-70 and serum creatinine expression were risk factors affecting the prognosis of CHF.ROC analysis showed that the AUC value predicted by serum CF-6 combined with HSP-70 for the prognosis of CHF was higher than that predicted by CF-6 and HSP-70 alone(P<0.05).Conclusion The expression levels of CF-6 and HSP-70 in the serum of CHF patients are obviously increased,and they increase with the aggravation of the disease.The two have certain clinical value in evaluating the prognosis of CHF patients.关键词
慢性心力衰竭/线粒体偶联因子-6/热休克蛋白70/预后Key words
chronic heart failure/mitochondrial coupling factor 6/heat shock protein 70/prognosis分类
医药卫生引用本文复制引用
李雅兰,喻洪..血清CF-6、HSP-70表达对慢性心力衰竭患者病情及预后的评估价值[J].四川医学,2024,45(5):507-511,5.
