老年卵巢癌患者临床特征及预后分析OACSTPCD

Objective:To investigate the clinical features,treatment characteristics and the prognostic factors of elderly patients with ovarian cancer.Methods:In this retrospective study,the clinical and survival data of 48 patients with ovarian cancer aged 70 years or older who were treated in Shaanxi Provincial Cancer Hospital from June 2021 to June 2023 were col-lected,and the clinical characteristics and prognosis influencing factors were described and analyzed.Results:93.7％(45/48)of the elderly patients with ovarian cancer were diagnosed as stage Ⅲ～Ⅳ.Only half received the standard treatment which includes surgery and chemotherapy with or without maintenance therapy,with no serious postoperative complications or chemotherapy side effects.Gene testing during treatment was conducted in 7 patients.The study found that standard treat-ment(P=0.001),maintenance therapy(P＜0.001),surgery(P=0.001),and R0 resection(P=0.002)were linked to improved progression-free survival(PFS).Conversely,factors like age,stage,and neoadjuvant chemotherapy did not signifi-cantly impact PFS(all P＞0.05).Age,stage,standard treatment and maintenance treatment have a certain impact on overall survival(OS).Older age(P=0.005)and advanced stage(P=0.049)were associated with poorer OS,while standard treatment(P＜0.001)and maintenance therapies(P=0.014)were linked to better OS.Multivariate analysis revealed that both standard treatment(HR=0.424,95％CI:0.186～0.967,P=0.041)and maintenance treatment(HR=0.077,95％CI:0.010～0.584,P=0.013)were identified as independent prognostic factors for PFS,whereas standard treatment(HR=0.053,95％CI:0.007～0.435,P=0.006)emerged as an independent prognostic factor for OS.Conclusion:The majority of elderly patients with ovarian cancer were diagnosed at an advanced stage,and a low proportion of patients received standard treatment and gene testing.However,standard treatment and maintenance therapy have a positive impact on the prognosis of patients.