肿瘤预防与治疗2024，Vol.37Issue(5)：405-412,8.DOI:10.3969/j.issn.1674-0904.2024.05.006
老年卵巢癌患者临床特征及预后分析
Clinical Characteristics and Prognosis of Elderly Patients with Ovarian Cancer
摘要
Abstract
Objective:To investigate the clinical features,treatment characteristics and the prognostic factors of elderly patients with ovarian cancer.Methods:In this retrospective study,the clinical and survival data of 48 patients with ovarian cancer aged 70 years or older who were treated in Shaanxi Provincial Cancer Hospital from June 2021 to June 2023 were col-lected,and the clinical characteristics and prognosis influencing factors were described and analyzed.Results:93.7％(45/48)of the elderly patients with ovarian cancer were diagnosed as stage Ⅲ～Ⅳ.Only half received the standard treatment which includes surgery and chemotherapy with or without maintenance therapy,with no serious postoperative complications or chemotherapy side effects.Gene testing during treatment was conducted in 7 patients.The study found that standard treat-ment(P=0.001),maintenance therapy(P＜0.001),surgery(P=0.001),and R0 resection(P=0.002)were linked to improved progression-free survival(PFS).Conversely,factors like age,stage,and neoadjuvant chemotherapy did not signifi-cantly impact PFS(all P＞0.05).Age,stage,standard treatment and maintenance treatment have a certain impact on overall survival(OS).Older age(P=0.005)and advanced stage(P=0.049)were associated with poorer OS,while standard treatment(P＜0.001)and maintenance therapies(P=0.014)were linked to better OS.Multivariate analysis revealed that both standard treatment(HR=0.424,95％CI:0.186～0.967,P=0.041)and maintenance treatment(HR=0.077,95％CI:0.010～0.584,P=0.013)were identified as independent prognostic factors for PFS,whereas standard treatment(HR=0.053,95％CI:0.007～0.435,P=0.006)emerged as an independent prognostic factor for OS.Conclusion:The majority of elderly patients with ovarian cancer were diagnosed at an advanced stage,and a low proportion of patients received standard treatment and gene testing.However,standard treatment and maintenance therapy have a positive impact on the prognosis of patients.关键词
卵巢癌/老年患者/化疗/手术/维持治疗Key words
Ovarian cancer/Elderly patients/Chemotherapy/Surgery/Maintenance therapy分类
医药卫生引用本文复制引用
王小伟,申娅辉,胡丽娟,席儒兴,王静,张鹏闯,王国庆..老年卵巢癌患者临床特征及预后分析[J].肿瘤预防与治疗,2024,37(5):405-412,8.基金项目
This study was supported by grants from Shaanxi Provincial Cancer Hospital(No.SC23A07). 陕西省肿瘤医院国家自然科学基金孵育项目(编号:SC23A07) （No.SC23A07）
