肿瘤预防与治疗2024，Vol.37Issue(5)：413-420,8.DOI:10.3969/j.issn.1674-0904.2024.05.007
基于生信分析探索IL4I1表达对卵巢癌的影响
Effectof IL4I1 Expression on Ovarian Cancer Based on Bioinformatics Analysis
封露 1李俊杨 2张国楠 3王登凤 2黄建鸣4
作者信息
- 1. 646000 四川泸州,西南医科大学附属医院肿瘤科
- 2. 610041 成都,四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院妇瘤科
- 3. 646000 四川泸州,西南医科大学附属医院肿瘤科||610041 成都,四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院妇瘤科
- 4. 610041 成都,四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院实验研究部
- 折叠
摘要
Abstract
Objective:The purpose of this study was to examine how interleukin-4 induced-1 protein(IL4I1)is expressed in ovarian cancer(OC)and its clinical implication.Methods:Relevant data were obtained from TCGA and GTEx databases to analyze the differential expression of IL4I1 in OC tissue and normal ovarian tissue.Immunohistochemical images were taken from the HPA database,and RNA-seq was used to detect the expression level of IL4I1 in OC.And its impact on the prognosis of OC patients was assessed by Kaplan-Meier plotter.Gene set enrichment analysis(GSEA)was used to explore IL4I1-related biological functions and signaling pathways.Correlation between IL4I1 expression and the level of immune cell infiltration was analyzed based on the CIBERSORT algorithm using the TIMER database.Results:IL4I1 expression in OC tissue was significantly higher than that in normal ovarian tissue(P＜0.001),and IL4I1 was linked to poor progression-free survival(PFS)in OC patients(P＜0.05).GSEA results suggested that IL4I1 may be involved in regulating IL6-JAK-STAT3 and PI3K-AKT-MTOR pathways.TIMER results revealed that IL4I1 expression level was positively correlated to the infiltration levels of B cells(r=0.190,P＜0.05),CD4+T cells(r=0.289,P＜0.05),neutrophils(r=0.373,P＜0.05),and dendritic cells(r=0.322,P＜0.05)in OC.Conclusion:IL4I1 is highly expressed in OC and is related to the tumor immunity of OC,it may promote the occurrence and development of OC through IL6-JAK-STAT3 and PI3K-AKT-MTOR pathways,which has potential as a diagnostic and therapeutic target for OC.关键词
卵巢癌/白细胞介素4诱导蛋白1/基因富集分析/肿瘤免疫Key words
Ovarian Cancer/Interleukin-4 induced 1 protein/Gene set enrichment analysis/Tumor immunity分类
医药卫生引用本文复制引用
封露,李俊杨,张国楠,王登凤,黄建鸣..基于生信分析探索IL4I1表达对卵巢癌的影响[J].肿瘤预防与治疗,2024,37(5):413-420,8.
