术前预康复在晚期卵巢癌患者中的临床应用效果OACSTPCD
Clinical Effect of Preoperative Prehabilitation in Patients with Advanced Ovarian Cancer
目的:分析探讨术前预康复模式应用于晚期卵巢癌患者中的临床效果及可行性.方法:回顾性分析2022年1月至2023年12月在陆军军医大学第一附属医院妇科完成新辅助化疗联合间歇性肿瘤细胞减灭术治疗的80例晚期卵巢癌患者病历资料.根据术前康复决策不同分为对照组40例,实施常规护理措施;试验组40例,在常规护理基础上实施术前预康复计划,比较两组患者新辅助化疗前1 d、手术前1 d及术后30 d的6 min步行距离、血清白蛋白水平、血红蛋白水平、术后30 d并发症发生率及术后康复指标的差异.结果:手术前1 d,试验组6 min步行距离大于对照组[(434.00±17.79)m vs(421.08±19.70)m](P=0.003),试验组血清白蛋白水平和血红蛋白水平均高于对照组[(42.68±2.09)g/L vs(40.33±5.31)g/L](P=0.011)、[(114.33±8.44)g/L vs(108.20±15.77)g/L](P=0.034);术后 30 d,试验组 6 min 步行距离大于对照组[(440.26±10.56)m vs(426.50±17.65)m](P＜0.001),试验组血清白蛋白水平和血红蛋白水平均高于对照组[(42.06±2.89)g/L vs(40.50±3.60)g/L](P=0.035)、[(113.53±6.50)g/L vs(104.10±11.90)g/L](P＜0.001);试验组与对照组术后 30 d 并发症发生率[(25.00％)10/40 vs(37.50％)15/40](P=0.045)、华西心晴指数评分、住院总天数、术后住院天数、住院总费用比较差异均具有统计学意义(P＜0.05).结论:术前预康复能提高晚期卵巢癌患者的运动能力,改善营养状态,降低术后并发症发生率,缩短住院时间,促进患者的加速康复.
Objective:To analyze and discuss the clinical effects and feasibility of preoperative rehabilitation model ap-plied to patients with advanced ovarian cancer.Methods:A retrospective analysis was conducted on the data of 80 patients with advanced ovarian cancer who underwent neoadjuvant chemotherapy combined with interval debulking surgery in the de-partment of gynecology in the First Affiliated Hospital of Army Medical University from January 2022 to December 2023.Ac-cording to different preoperative rehabilitation decisions,patients were assigned to a control group of 40 cases,implementing routine nursing measures;and an experiment group of 40 cases,implementing preoperative prehabilitation plan on the basis of routine nursing.The differences in 6-mi-nute walk distance(6MWD),serum albumin level and hemo-globin level 1day before neoadjuvant chemotherapy,1day before surgery and 30days after surgery as well as the incidence rates of postoperative complications and postoperative recovery indicators between the two groups were compared.Results:1day before surgery,the experiment group had a greater 6MWD than the control group[(434.00±17.79)m vs(421.08± 19.70)m,P=0.003)];the serum albumin level and hemoglobin level in the experiment group were higher than those in the control group[(42.68±2.09)g/L vs(40.33±5.31)g/L,P=0.011;(114.33±8.44)g/L vs(108.20±15.77)g/L,P=0.034].At 30 days after surgery,the experimental group's 6MWD was greater than that of the control group[(440.26±10.56)m vs(426.50±17.65)m,P＜0.001);the serum albumin level and hemoglobin levels were higher than those in the control group[(42.06±2.89)g/L vs(40.50±3.60)g/L,P=0.035;(113.53±6.50)g/L vs(104.10±11.90)g/L,P＜0.001].Differences in the incidence rate of 30-day postoperative complications[25.00％(10/40)vs 37.50％(15/40),P=0.045],Huaxi Emotional-Distress Index,total length of days,postoperative length of days and total hospital costs were all statistically significant between the experiment group and the control group(P＜0.05).Conclusion:Preoperative prehabilitation is helpful in improving exercise capacity,nutritional status,reducing the incidence of postoperative complications,shortening length of stay,and promoting enhanced recovery after surgery for patients with ad-vanced ovarian cancer.
荣欣;吴治敏;王艳;陈彦丽;李玲;邓黎
400038 重庆,陆军军医大学第一附属医院妇产科
临床医学
晚期卵巢癌新辅助化疗术前预康复加速康复术后并发症
Advanced ovarian cancerNeoadjuvant chemotherapyPreoperative prehabilitationERASPostoperative complications
《肿瘤预防与治疗》 2024 (005)
421-428 / 8
This study was supported by grants from Chongqing Science and Technology Bureau and Health Commis-sion of Chongqing(No.2024MSXM018). 重庆市科卫联合医学科研项目(编号:2024MSXM018)
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