摘要
Abstract
Objectives To investigate the application effect of acupuncture combined with sour jujube nut soup by the method of harmonizing yin and yang in elderly chronic heart failure with sleep disorders,and to analyze the possible mechanism of its ex-erting efficacy.Methods Eighty-six elderly patients with chronic heart failure with sleep disorders admitted to our hospital from January 2022to June 2023were selected for the study,and they were divided into the control group(n=42)and the study group(n=44)according to the treatment plan;the control group was given conventional treatment combined with sour jujube nut soup,and the study group was given acupuncture combined with sour jujube nut soup by the method of regulating yin and yang,all of them were continued to be treated for 1month.The clinical efficacy,Pittsburgh Sleep Quality Index(PSQI)scores,N-terminal B-type brain natriuretic peptide precursor(NT-proBNP),serum neurotransmitter indexes,and Chinese medicine syndrome scores were compared between the two groups,and the adjuvant T-lymphocyte(Th)1/Th2cytokines and Th1/Th2ratios were de-tected and compared before and after treatment.Results The total clinical treatment efficiency of the study group after treatment was higher than that of the control group(P＜0.05).PSQI scores and serum NT-proBNP levels were lower in the study group af-ter treatment compared to the control group(P＜0.05).After treatment,the TCM symptom scores of chest tightness,fatigue,swelling of facial limbs,palpitations,shortness of breath,and wheezing of the patients in the study group were lower than those of the control group(P＜0.05),and the improvement of 5-hydroxytryptamine(5-HT),norepinephrine(NE),dopamine(DA),and γ-aminobutyric acid(GABA)was better than that of the control group(P＜0.05).After treatment,the levels of interleukin(IL)-1,IL-2,and Th1/Th2ratio were lower in the study group than in the control group,whereas the levels of IL-4and IL-10were higher than in the control group(P＜0.05).Conclusion The combination of acupuncture and sour jujube nut soup with the method of harmonizing yin and yang may be more effective in improving the clinical outcomes of elderly patients with chronic heart failure and sleep disorders,which may be related to the modulation of the Th1/Th2cell balance and the improvement of the body's inflammatory response.关键词
调和阴阳法针灸/酸枣仁汤/慢性心力衰竭/睡眠障碍/疗效/机制Key words
Harmonization of Yin and Yang method of acupuncture/Sour date kernel soup/Chronic heart failure/Sleep disorder/Healing effect/Machine分类
医药卫生
