药学研究2024，Vol.43Issue(5)：435-438,454,5.DOI:10.13506/j.cnki.jpr.2024.05.004
染料木素邻苯二甲酰亚胺衍生物合成及其抗乳腺癌活性研究
Synthesis and anti-breast cancer activity of phthalimide derivatives of genistein
摘要
Abstract
Objective To study the anti-breast cancer activity and mechanism of phthalimide derivatives of genistein in vitro.Methods Phthalimide derivatives of genistein were prepared and their anti-proliferative effects of MCF-7,MDA-MB-231,MDA-MB-435,and MCF-10A cell lines were evaluated by standard MTT method.Molecular docking was used to explore the interaction between the synthesized compounds and estrogen receptor α(ERα).Results Three phthalimide derivatives of genistein were synthesized and their bioactivity and anti-breast cancer mechanism were verified.Conclusion The designed phthalimide derivatives of genistein possess potent anti-breast cancer activity may act as competitive inhibition of ERα and other mechanisms.关键词
染料木素/邻苯二甲酰亚胺/衍生物/抗乳腺癌活性/分子对接Key words
Genistein/Phthalimide/Derivatives/Anti-breast cancer activities/Molecular docking分类
药学引用本文复制引用
郑兴,孙林军,朱颖丽,姚旭..染料木素邻苯二甲酰亚胺衍生物合成及其抗乳腺癌活性研究[J].药学研究,2024,43(5):435-438,454,5.基金项目
湖南省自然科学基金项目(No.2020JJ6052、2021JJ80015) （No.2020JJ6052、2021JJ80015）
中国科学院有机氟化学重点实验室(No.2018-10) （No.2018-10）
