饲料研究2024，Vol.47Issue(9)：84-88,5.DOI:10.13557/j.cnki.issn1002-2813.2024.09.015
基于网络药理学探讨功苋止痢散治疗仔猪腹泻的作用机制
Exploring mechanism of Gong Xian Zhi Li San in treating piglet diarrhea based on network pharmacology
摘要
Abstract
The article aimed to investigate the main chemical components and their mechanism of action of Gong Xian Zhi Li San for the treatment of piglet diarrhea based on network pharmacology.The effective components and pathways of Gong Xian Zhi Li San were determined by databases(TCMSP,Herb,OMIM,BIOGPS,etc.).The results showed that a total of 49 active components were collected,including three Mahonia fortunei(Lindl.)Fedde,four Ilex rotunda Thunb,24 Sophora flavescens Aiton,six Geranium wilfordii Maxim,and 12 Acalypha australis L..According to Degree value,the top five components were quercetin,kaempferol,luteolin,β-sitosterol,and palmatine.There were 262 corresponding targets,and the key targets were RELA,MAPK3,MAPK1,HSP90AA1,TNF,and so on.There were 4 012 GO entries,206 CC entries,3 459 BP entries,and 347 MF entries by GO enrichment analysis.The KEGG pathway was enriched with 230 signal pathways,and the targets were mainly acting on the AGE-RAGE,IL-17,and TNF signaling pathways.The study indicates that Gong Xian Zhi Li San improve piglet diarrhea by the regulating AGE-RAGE signal pathway,IL-17 signal pathway,and TNF signal pathway through the action of quercetin,kaempferol,luteolin,β-sitosterol,and palmatine on RELA,MAPK3,MAPK1,HSP90AA1,and TNF.关键词
功苋止痢散/网络药理学/仔猪/腹泻Key words
Gong Xian Zhi Li San/network pharmacology/piglet/diarrhea分类
农业科技引用本文复制引用
白家成,钟丽蝶,李涪锌,孙雪芳,王春花..基于网络药理学探讨功苋止痢散治疗仔猪腹泻的作用机制[J].饲料研究,2024,47(9):84-88,5.基金项目
黑龙江自然科学基金项目(项目编号:LH2021C096) （项目编号:LH2021C096）
黑龙江省博士后面上项目(项目编号:LBH-Z21102) （项目编号:LBH-Z21102）
牡丹江师范学院研究生科技创新项目(项目编号:kjcx2022-008mdjnu) （项目编号:kjcx2022-008mdjnu）
黑龙江省教育厅青年培育项目(项目编号:1353MSYQN014) （项目编号:1353MSYQN014）
