甲状腺功能亢进症患者甲状腺激素水平变化及其与冠心病发生关系研究OACSTPCD

Objective:To observe the changes of thyroid hormone levels in patients with hyperthyroidism,and to analyze their relationship with occurrence of coronary heart disease(CHD).Methods:A total of 144 patients with hy-perthyroidism were selected and divided into study group(hyperthyroidism complicated with CHD,68 cases)and control group(simple hyperthyroidism,76 cases)according to whether they had CHD or not.The general data and thyroid hormone levels of the two groups were compared.Logistic regression was used to analyze the influencing fac-tors of CHD in patients with hyperthyroidism.ROC curve was used to analyze the predictive value of thyroid hor-mone for hyperthyroidism complicated with CHD.Pearson correlation analysis was used to analyze the relationship between the number of coronary artery lesions and thyroid hormone levels.Results:The age,smoking history,TG and TSH levels of the study group were higher than those of the control group,and FT3 level was lower than that of the control group(all P＜0.05).Age,smoking history,TG,FT3 and TSH levels were independent influencing factors for CHD in patients with hyperthyroidism(all P＜0.05).Age,TG,FT3 and TSH had certain predictive value for hyperthyroidism complicated with CHD(all P＜0.05),and FT3 had a higher sensitivity in predicting hyperthyroidism combined with CHD,and TSH had a higher specificity.TSH level in multi-vessel disease group was higher than that in double-vessel disease group and single-vessel disease group,and TSH level in double-vessel disease group was higher than that in single-vessel dis-ease group(all P＜0.05).The number of diseased coronary vessels was positively correlated with TSH level(r=0.469,P＜0.05).Conclusion:FT3 and TSH levels have high predictive value for CHD in patients with hyperthyroidism,and TSH level is closely related to the number of diseased coronary vessels in patients with hyperthyroidism and CHD.