陕西医学杂志2024，Vol.53Issue(6)：768-772,5.DOI:10.3969/j.issn.1000-7377.2024.06.010
血清25羟维生素D、甲状旁腺激素、总Ⅰ型胶原氨基端延长肽/β-胶联降解产物水平与老年骨质疏松症患者胸腰椎压缩性骨折关系及检测意义
Relationship between serum 25-OH-VD,PTH,t-PINP/β-CTX and osteoporotive vertebral compression fractures in elderly patients osteoporosis and their detection significance
摘要
Abstract
Objective:To explore the relationship between serum 25-hydroxyvitamin D(25-OH-VD),parathy-roid hormone(PTH),ratio of total type Ⅰ collagen amino terminal extender peptide(t-PINP)/β-gel linked degrada-tion products(β-CTX)and osteoporotive vertebral compression fractures(OVCF)in elderly osteoporosis patients and their detection significance.Methods:A total of 36 elderly patients with OVCF were enrolled as OVCF group,and 72 elderly osteoporosis patients without fracture during same period were enrolled as control group.The general data,levels of serum 25-OH-VD,PTH,t-PINP,β-CTX,TRAP5b,t-PINP/β-CTX and bone mineral density(BMD)were compared between the two groups.The correlation between serum bone turnover markers and BMD,and the influen-cing factors of OVCF in elderly patients with osteoporosis,and the diagnostic value of serum bone turnover markers for OVCF in elderly patients were analyzed.Results:The levels of serum 25-OH-VD and β-CTX in OVCF group were lower than those in control group,while levels of PTH,t-PINP,TRAP5b and t-PINP/β-CTX were higher than those in control group(all P＜0.05).The lumbar BMD and total hip BMD in OVCF group were lower than those in control group(all P＜0.05).Pearson correlation analysis showed that lumbar BMD and total hip BMD were positive-ly correlated with serum 25-OH-VD and β-CTX,while negatively correlated with PTH,t-PINP,TRAP5b,t-PINP/β-CTX(all P＜0.05).Multivariate Logistic regression analysis showed that low levels of serum 25-OH-VD and β-CTX,and high levels of PTH,t-PINP and t-PINP/β-CTX were influencing factors for OVCF in elderly patients with osteoporo-sis(all P＜0.05).Serum 25-OH-VD,PTH,t-PINP,β-CTX and t-PINP/β-CTX had certain value in the diagnosis of OVCF in the elderly(all P＜0.05).Conclusion:The decrease of serum 25-OH-VD,the increase of serum PTH and t-PINP/β-CTX are correlated with the occurrence of OVCF in elderly patients with osteoporosis,and they all have certain diagnostic value for the occurrence of OVCF in elderly patients with osteoporosis.关键词
骨质疏松性胸腰椎压缩性骨折/25羟维生素D/甲状旁腺激素/总Ⅰ型胶原氨基端延长肽/β-胶联降解产物/老年人Key words
Osteoporotic thoracolumbar compression fracture/25-hydroxyvitamin D/Parathyroid hormone/Total type Ⅰ collagen amino terminal extender peptide/β-gel linked degradation product/Old people分类
医药卫生引用本文复制引用
秦华,覃海,宋晓钰,杨永红..血清25羟维生素D、甲状旁腺激素、总Ⅰ型胶原氨基端延长肽/β-胶联降解产物水平与老年骨质疏松症患者胸腰椎压缩性骨折关系及检测意义[J].陕西医学杂志,2024,53(6):768-772,5.基金项目
贵州省卫生计划生育委员会科学技术基金资助项目(GZWKJ2013-1-099) （GZWKJ2013-1-099）
