陕西医学杂志2024，Vol.53Issue(6)：797-800,805,5.DOI:10.3969/j.issn.1000-7377.2024.06.016
超早期小骨窗微创术治疗高血压脑出血疗效及对核因子-κB p65通路的影响
Efficacy of ultra-early small bone window minimally invasive surgery on hypertensive intracerebral hemorrhage and its effect on nuclear factor-κB p65 pathway
摘要
Abstract
Objective:To analyze the efficacy of ultra-early small bone window minimally invasive surgery in treatment of hypertensive cerebral hemorrhage and its effect on nuclear factor-κB p65(NF-κB p65)pathway.Meth-ods:A total of 86 patients with hypertensive intracerebral hemorrhage were divided into observation group(46 cases,underwent small bone window minimally invasive intracranial hematoma removal within 6 hours of onset)and con-trol group(40 cases,underwent small bone window minimally invasive intracranial hematoma removal within 6 to 24 hours of onset).The clinical efficacy,perioperative indicators,cerebral blood flow perfusion indicators,traumatic stress indicators of brain tissue,NF-KB p65 pathway-related factors and complications were compared between two groups.Results:The total effective rate in observation group was higher than that in control group(P＜0.05).Com-pared with control group,the intraoperative blood loss was higher,but the recovery time of consciousness,time to get out of bed,and length of hospital stay were shorter in the observation group(all P＜0.05).Compared with pre-oper-ation,the levels of EDV,PSV of middle cerebral artery and serum BDNF were increased 7 days after operation in the two groups,and the observation group was higher;the RI of the middle cerebral artery and R of the common carotid artery on the affected side in the two groups decreased,and the serum levels of NPY,S100β,IL-6,TNF-α,and NF-κB p65 decreased,and the observation group was lower(all P＜0.05).The total incidence of complications during hospitali-zation in the observation group was lower than that in control group(P＜0.05).Conclusion:Compared with surgery performed within 6 to 24 hours of onset,small bone window minimally invasive surgery performed within 6 hours of onset has better efficacy.It can not only improve perioperative indicators,reduce traumatic stress,improve cerebral blood perfusion,but also regulate NF-κB p65 pathway,with higher safety.关键词
高血压脑出血/超早期小骨窗微创术/创伤应激/核因子-κB p65/脑血流灌注/安全性Key words
Hypertensive cerebral hemorrhage/Ultra-early small bone window minimally invasive surgery/Traumatic stress/Nuclear factor-κB p65/Cerebral blood flow perfusion/Safety分类
医药卫生引用本文复制引用
赵立辉,王立忠,袁进国,袁武,侯青,孙慧渊,王唯..超早期小骨窗微创术治疗高血压脑出血疗效及对核因子-κB p65通路的影响[J].陕西医学杂志,2024,53(6):797-800,805,5.基金项目
河北省卫生健康委员会医学科学研究课题(20191722) （20191722）
