吉马酮抑制JAK2/STAT3信号通路对食管癌细胞增殖、凋亡和侵袭的影响OACSTPCD
Influences of germacrone on proliferation,apoptosis and invasion of esophageal cancer cells by inhibiting JAK2/STAT3 signaling pathway
目的 探讨吉马酮抑制蛋白酪氨酸激酶2(Janus kinase 2,JAK2)/信号转导子与激活子3(signal transducer and activator of transcription 3,STAT3)信号通路对食管癌细胞增殖、凋亡和侵袭的影响.方法 甲基噻唑蓝(methyl thiazolyl tetrazolium,MTT)法检测不同浓度(0、10、20、40、80、160和320 μmol/L)的吉马酮分别处理人食管癌细胞Ec…查看全部>>
Objective To investigate the influences of germacrone on the proliferation,apoptosis and invasion of esophageal cancer cells by inhibiting Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway.Methods Meth-yl thiazolyl tetrazolium(MTT)assay was used to detect the survival rates of esophageal cancer cells Eca109 and KYSE450 and human esophageal epithelial cells Het-1A treated with germacrone at different concentration…查看全部>>
马骏;刘倩;王孝彬
空军军医大学第二附属医院/唐都医院胸腔外科,陕西西安 710038空军军医大学第二附属医院/唐都医院胸腔外科,陕西西安 710038空军军医大学第二附属医院/唐都医院胸腔外科,陕西西安 710038
食管癌吉马酮JAK2/STAT3通路细胞增殖细胞凋亡细胞侵袭
esophageal cancergermacroneJAK2/STAT3 pathwaycell proliferationcell apoptosiscell invasion
《实用肿瘤杂志》 2024 (3)
228-235,8
陕西省重点研发计划项目(2022SF-230)
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