自动uARC计划在左侧乳腺癌同步加量调强放疗中的可行性研究OACSTPCD

Objective To compare dosimetric parameters and normal tissue complication probability(NTCP)between automated uARC plan and manual plan in the simultaneous integrated boost(SIB)intensity-modulated radiotherapy(IMRT)of patients with left breast can-cer in order to investigate the feasibility of automated uARC planning.Methods Twenty-one patients with left breast cancer after breast conserving surgery who underwent SIB-IMRT in Henan Provincial People's Hospital from May 2021 to May 2022 were retrospectively se-lected.Automated uARC plan and manual plan were generated with the uRT-TPOIS treatment planning system(TPS)for each patient.The differences in the D2％,D98％,mean dose(Dmean),homogeneity index(HI)and conformity index(CI)of targets,dosimetric parameters of organs at risk(OARs),planning time and monitor unit(MU)were compared between automated and manual plans.NTCP for the ipsilateral lung,contralateral lung and heart were also analyzed.Results The HI,CI,Dmean and V50 of automated plan were better than those of manual plan(all P＜0.05).The manual plan had a higher D98％for planning target volume(PTV)with prescribed dose of 60 Gy(PTV60)than automated plan(P＜0.05).The mean doses of ipsilateral lung and heart of the automated plan were better than those of the manual plan[(9.35±0.47)Gy vs(9.61±0.37)Gy,(7.66±1.18)Gy vs(8.50±1.10)Gy,both P＜0.05].No significant differences were found in the V30 of ipsilat-eral lung and heart(both P＞0.05).Automated plan had a significantly shorter planning time than manual plan[(25.00±2.30)min vs(64.57±7.17)min,P＜0.01].There was no signifcant difference in MU between automated and manual plans(P=0.207).Lung NTCP and heart NTCP were lower in automated plan than those in manual plan(all P＜0.01).Conclusions It is feasible to generate automated uARC plan with uRT-TPOIS TPS for breast cancer patients.Automated uARC plan improves the dose coverage of PTV and reduce the planning time compared with manual plan.