摘要
Abstract
Objective To investigate the diagnostic value of 18F-fluorodexyglucose(18F-FDG)PET/CT and prostate serological indicators in prostate tumor.Methods A total of 95 patients with 18F-FDG PET/CT and serological indicators performed for prostate lesions con-firmed by pathology at the Second Affiliated Hospital,Zhejiang University School of Medicine,from August 2013 to December 2021,were analyzed retrospectively.The patients were divided into malignant group(n=77)and benign group(n=18).Receiver operating characteristic(ROC)curves were used to find out the cut-off value of the maximum standardized uptake value(SUVmax),total prostate specific antigen(tPSA),free prostate specific antigen(fPSA),and free/total prostate specific antigen(f/t-PSA)for diagnosing prostate tumor.Results ROC curves showed that the cut-off values of SUVmax,tPSA,fPSA,and f/t-PSA for diagnosing malignant prostate lesions were 4.47,46.67 ng/mL,11.11 ng/mL,and 0.10.The areas under the curves(AUCs)for SUVmax,tPSA,fPSA,and f/t-PSA were 0.658,0.897,0.842,and 0.836.The sensitivity,specificity,and accuracy value obtained by 18F-FDG PET/CT were 81.8％,61.1％,and 77.9％,respectively,97.4％,27.8％,and 84.2％by tPSA,92.2％,50.0％,and 84.2％by fPSA,and 83.1％,50.0％,and 76.8％by f/t-PSA.SUVmax,tPSA,and fPSA in the malignant group were all significantly higher than those in the benign group(all P＜0.05).f/t-PSA in the malignant group was significantly lower than that in the benign group(P＜0.05).18F-FDG PET/CT showed 72 patients with metastatic lesions.Conclusions SUVmax,tPSA,fPSA,and f/t-PSA were effective indicators to identify benign and malignant prostate lesions.18F-FDG PET/CT was more advantageous in exploring distant le-sions,providing better assistance for clinical decisions.关键词
前列腺肿瘤/PET/CT/最大标准摄取值/前列腺特异性抗原Key words
prostate tumor/PET/CT/maximum standardized uptake value/prostate specific antigen
