特产研究2024，Vol.46Issue(3)：72-79,8.DOI:10.16720/j.cnki.tcyj.2023.096
丹参-三七治疗膝骨关节炎的网络药理学机制研究
Study on Notwork Pharmacological Mechanism of Danshen and Sanqi in the Treatment of Knee Osteoarthritis
摘要
Abstract
To provide theoretical support for the clinical application of Danshen and Sanqi in the treatment of knee osteoarthritis(KO A),an exploration on the potential mechanism was performed using network pharmacology and molecular docking.TCMSP database was used to search the main compounds and related targets.GeneCards,OMIM,and DisGeNET databases were used to search the targets of KOA.The intersection targets of Danshen-Sanqi and KOA were obtained by Venn diagram.The composition-target-disease network and PPI network were constructed by using STRING database and Cytoscape software,and the core components and targets were screened.GO functional analysis and KEGG pathway enrichment analysis were performed through DAVID database.AutoDock software was used for molecular docking.A total of 66 active components and 232 related targets were obtained from Danshen-Sanqi.There were 130 intersection targets.Quercetin,luteolin,and tanshinone ⅡA were the core compounds,PTGS2,ADRB2 and OPRM1 were the core targets.GO functional analy-sis obtained 794 entries and KEGG analysis obtained 141 related pathways.Molecular docking results showed that tanshinone ⅡA had a good affinity with ADRB2.The mechanisms of Danshen-Sanqi treatment for KOA mainly involve cancer pathway,AGE-RAGE signaling pathway,lipid metabolism,fluid shear stress signaling pathways,etc.Tanshinone ⅡA and ADRB2 may be the key component and target.关键词
丹参/三七/膝骨关节炎/网络药理学/分子对接Key words
Danshen/Sanqi/knee osteoarthritis/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
吴金仓,张宵元,叶阳..丹参-三七治疗膝骨关节炎的网络药理学机制研究[J].特产研究,2024,46(3):72-79,8.基金项目
中国博士后科学基金面上资助项目(2019M650393) （2019M650393）
