特产研究2024，Vol.46Issue(3)：113-122,10.DOI:10.16720/j.cnki.tcyj.2023.062
基于网络药理学和分子对接探讨黄芪-川芎配伍治疗瘢痕的作用机制
Based on Network Pharmacology and Molecular Docking to Explore the Mechanism of Astragalus Membranaceus-Ligusticum sinense Combination in Treating Scar
摘要
Abstract
To explore the mechanism of the combination of Astragalus membranaceus-Ligusticum sinense in the treatment of scar through network pharmacology.The effective components and their targets of A.membranaceus and L.sinense were screened by TCMSP database.Scar targets were obtained using OMIM,GeneCards and DrugBank databases.The intersection target of A.membranaceus and L.sinense in the treatment of scar was obtained.Cytoscape 3.7.0 software was used to construct TCM-active ingredient-target-disease network.Construct PPI network through STRING database.KEGG enrichment and GO fuction analysis were visualized using Weisheng website.It is verified by molecular docking.A total of 7 active ingredients of L.sinense were screened,which corresponded to 42 targets.There were 20 active ingredients of A.membranaceus,corresponding to 462 targets.There were 2 216 scar targets.The key ingredients of A.membranaceus-L.sinense combination in treating scar include quercetin and kaempferol.The key targets of scar treatment are TP53 and interleukin 6.KEGG enrichment analysis showed that it was mainly related to IL-17 signaling pathway and TNF signaling pathway.Molecular docking showed that the main active components had good stability with the key targets.Based on the analysis of network pharmacology and molecular doc-king verification,this paper shows that A.membranaceus and L.sinense may treat scar through multi-component,multi-target and multi-pathway.关键词
黄芪/川芎/瘢痕/网络药理学Key words
Astragalus membranaceus/Ligusticum sinense/scar/network pharmacology分类
医药卫生引用本文复制引用
洪玉书,宋张婕,张佳欢,刘婧,李玉梅..基于网络药理学和分子对接探讨黄芪-川芎配伍治疗瘢痕的作用机制[J].特产研究,2024,46(3):113-122,10.基金项目
省级大学生创新创业训练计划项目(S202110199056) （S202110199056）
长春中医药大学"杏林学者工程"青年科学家计划项目 （）
