平均血小板体积对血液透析患者急性缺血性脑血管病事件的预测价值OACSTPCD

Objective To investigate the correlation between mean platelet volume(MPV)and acute ischaemic cerebrovascu-lar events(AICE)in haemodialysis(MHD)patients,and to evaluate the predictive value of MPV for AICE events.Methods Patients with maintenance MHD in the Nephrology Department of Beijing Chaoyang Hospital from January 2015 to December 2021 were collected as study subjects(n=232),and according to the occurrence of acute ischaemic cerebrovascular disease events they were divided into the AICE group(n=77)and non-AICE group(n=155).Differences in MPV and clinical features were compared between the two groups.Univariate and multivariate Cox regression was used to analyze the independent risk factors for AICE,and receiver operating characteristic curve(ROC)was drawn to evaluate the predictive value of MPV for the risk of AICE in MHD patients.Results Com-pared with the non-AICE group,patients in AICE group had significantly higher MPV[10.7(10.3,11.3)fl vs.10.3(9.7,10.8)fl,Z=3.8938,P<0.001].Age,smoking,history of CAD,1-week mean ultrafiltration dehydrate volume,total cholesterol,LDL choles-terol,and triglyceride were all higher than those in non-AICE group,while albumin was lower than that in AICE group.Multivariate Cox regression showed that AIS history after correction,smoking,increased water removal by ultra-filtration,decreased albumin,and increased MPV[HR 1.601(1.219,2.102);P<0.001]were independent risk factors for AICE.The AUC of the ROC curve on MPV was 0.824,the specificity was 0.883 and the sensitivity was 0.716.Conclusions MPV is an independent risk factor for AICE in MHD patients and has good predictive value for AICE.