现代妇产科进展2024，Vol.33Issue(6)：445-450,6.DOI:10.13283/j.cnki.xdfckjz.2024.06.004
PRARGC1A基因多态性与孕前体重指数的交互作用对妊娠期糖尿病的影响
The interaction of PRARGC1A gene polymorphism and pre-pregnancy body mass index on gestational diabetes mellitus
摘要
Abstract
Objective:To investigate loci polymorphisms of the PRARGC1A gene rs8192678 and the association of gene-pre-pregancy body mass index(BMI)interaction with the susceptibility to gestational diabetes mellitus(GDM).Methods:A total of 292 GDM patients admitted for delivery in Gansu Provincial Maternal and Child Health Care Hospital from March 2021 to September 2021 were included as the case group,292 non-GDM pregnant women were 1∶1 matched with age in control group.rs8192678 gene polymorphism in peripheral blood and pre-pregancy BMI were detected.The association of gene-pre-pregancy BMI interaction with the susceptibility to GDM was analyzed.Results:Pre-pregnancy overweight/obesity(OR=2.36,95%CI:1.531～3.643)was associated with susceptibility to GDM.Carrying the CT+TT geno-type and TT genotype increased the risk of GDM.In addition,the dominant model(CT+TT)and the recessive model(TT)had combined effects with pre-pregnancy overweight/obesity,both increasing the risk of developing GDM.Conclusion:Pre-pregnancy overweight/obesity was a risk factor for GDM.The PRARGC1A gene rs8192678 locus might be a susceptible gene for GDM,and it interacted with pre-pregnancy overweight/obesity.关键词
妊娠期糖尿病/叉生分析/相乘交互作用/相加交互作用/Logistic回归Key words
Gestational diabetes mellitus/Crossover analysis/Multiplicative interac-tion/Additive interaction/Logistic regression分类
医药卫生引用本文复制引用
张喜荣,史绪生,李斐,郭志茹,易彬,王燕侠..PRARGC1A基因多态性与孕前体重指数的交互作用对妊娠期糖尿病的影响[J].现代妇产科进展,2024,33(6):445-450,6.基金项目
甘肃省自然科学基金项目(No:20JR10RA427) （No:20JR10RA427）
国家儿童健康与疾病临床医学研究中心项目(No:NCRCCHD-2020-GP-15) （No:NCRCCHD-2020-GP-15）
