PRARGC1A基因多态性与孕前体重指数的交互作用对妊娠期糖尿病的影响OACSTPCD

Objective:To investigate loci polymorphisms of the PRARGC1A gene rs8192678 and the association of gene-pre-pregancy body mass index(BMI)interaction with the susceptibility to gestational diabetes mellitus(GDM).Methods:A total of 292 GDM patients admitted for delivery in Gansu Provincial Maternal and Child Health Care Hospital from March 2021 to September 2021 were included as the case group,292 non-GDM pregnant women were 1∶1 matched with age in control group.rs8192678 gene polymorphism in peripheral blood and pre-pregancy BMI were detected.The association of gene-pre-pregancy BMI interaction with the susceptibility to GDM was analyzed.Results:Pre-pregnancy overweight/obesity(OR=2.36,95%CI:1.531～3.643)was associated with susceptibility to GDM.Carrying the CT+TT geno-type and TT genotype increased the risk of GDM.In addition,the dominant model(CT+TT)and the recessive model(TT)had combined effects with pre-pregnancy overweight/obesity,both increasing the risk of developing GDM.Conclusion:Pre-pregnancy overweight/obesity was a risk factor for GDM.The PRARGC1A gene rs8192678 locus might be a susceptible gene for GDM,and it interacted with pre-pregnancy overweight/obesity.