畜牧兽医学报2024，Vol.55Issue(5)：1866-1874,9.DOI:10.11843/j.issn.0366-6964.2024.05.005
CD46基因在家畜抗病育种中的应用研究进展
Progress on the Application of CD46 in Breeding of Livestock for Disease Resistance
摘要
Abstract
Complement regulatory protein 46(CD46)is widely expressed in most mammalian cells.In addition to its various physiological functions such as complement inactivation,regulation of T cell activation and fertility,CD46 can also serve as a receptor for various bacteria and viruses.It is especially important for the attachment of bovine viral diarrhea virus(BVDV)and classical swine fever virus(CSFV).The use of gene editing technology to specifically modify CD46 has successfully produced live calve that can resist BVDV infections,proving that this gene can be used as a candidate gene for disease resistance breeding.This article mainly reviews the role of CD46 protein in livestock virus infection and its application in disease resistance breeding.关键词
CD46/牛病毒性腹泻病毒/抗病育种Key words
CD46/bovine viral diarrhea virus/disease resistance breeding分类
农业科技引用本文复制引用
李剑南,袁利明,华进联..CD46基因在家畜抗病育种中的应用研究进展[J].畜牧兽医学报,2024,55(5):1866-1874,9.基金项目
国家重点研发计划项目(2022YFD1302201) （2022YFD1302201）
陕西省畜牧专项(20221086 （）
20230978) （）
内蒙古自治区揭榜挂帅项目(2022JBGUS0025) （2022JBGUS0025）
