畜牧兽医学报2024，Vol.55Issue(5)：1945-1957,13.DOI:10.11843/j.issn.0366-6964.2024.05.013
利用GWAS和DNA甲基化共定位鉴定猪肉质性状的候选基因
Identification of Candidate Genes for Pork Texture Traits Using GWAS Combined with Co-localisation of DNA Methylation
摘要
Abstract
To gain a deeper understanding of the genetic basis of meat quality traits,this study performed GWAS analysis using genotype-based populated sequencing data and co-localisation analysis with previously published EWAS results.The study identified 515 genome-wide significant SNP loci and 4 134 SNP loci at the proposed significance threshold,which involved 406 genes,including 262 protein-coding genes,and resulted in the identification of 6 important candidate genes that may be associated with meat quality traits.Meanwhile,comparison with the results of EWAS revealed that 12 significant CpG loci overlapped with significant SNP loci.The study results can provide a more solid theoretical foundation and data support for breeding efforts to improve pork quality.关键词
全基因组关联分析/SNPs/肉质性状Key words
genome-wide association study/SNPs/meat traits分类
农业科技引用本文复制引用
崔晟頔,陈佳苗,王翔枫,唐国庆,王凯,赵真坚,陈栋,申琦,余杨,王俊戈,陈子旸,禹世欣..利用GWAS和DNA甲基化共定位鉴定猪肉质性状的候选基因[J].畜牧兽医学报,2024,55(5):1945-1957,13.基金项目
四川省科技厅项目(2020YFN0024 （）
2021ZDZX0008 （）
2021YFYZ0030) （）
国家生猪技术创新中心先导科技项目(NCTIP-XD/B01) （NCTIP-XD/B01）
