刑事技术2024，Vol.49Issue(3)：279-283,5.DOI:10.16467/j.1008-3650.2023.0066
36个X-STR基因座在汉族人群中的遗传多态性荟萃分析
A Meta-analysis of Genetic Polymorphisms in 36 X-STR Loci in Han Population
摘要
Abstract
The aim of this study was to establish a comprehensive forensic reference for calculating likelihood ratios of different genetic relationships in the Chinese Han population.To achieve this,frequency parameters for 36 X-STR loci were determined.A notable limitation of previous literature reports was their reliance on small sample sizes,typically consisting of only 200-300 individuals.In contrast,our analysis incorporated data from over 1000 individuals sourced from 16 literature references,thereby ensuring a more robust and representative sample.The obtained allele frequency data for the 36 X-STR loci proved invaluable in forensic cases involving the Chinese Han population.This data was derived from an extensive collection of samples encompassing a total of 8 767 unrelated individuals hailing from diverse regions such as Guangdong,Henan,Yunnan,Beijing,Guzhou,Sichuan,Hainan and Hebei.Gene frequency parameters were carefully selected from these 16 literature sources to accurately represent the Chinese Han population.Multiple kits including Argus X12,Goldeye 17X,AGCU X19,Microreader X19,and Typer X19 were employed during data collection to ensure comprehensive coverage and accuracy.Across the 36 loci analyzed(including DXS6807,DXS9895,DXS10148,DXS10135,DXS8378,DXS9902,DXS6795,DXS6810,DXS10159,DXS10162,DXS10164,DXS7132,DXS10079,DXS10074,DXS10075,DXS981,DXS6800,DXS6803,DXS6809,DXS6789,DXS7424,DXS101,DXS7133,GATA172D05,GATA165B12,DXS10103,HPRTB,DXS10101,GATA31E08,DXS8377,DXS10134,DXS7423,DXS9907,DXS10146,DXS6797,DXS6804),a total of 572 alleles were identified with certain loci exhibiting notable increases in allele numbers such as DXS10135,DXS10134,DXS10148,and DXS10079,which indicated an increase by more than 5 alleles.To calculate allele frequencies across all 36 loci,a varying number(ranging from 1193 to 8767)of unrelated individuals were included in this study.DXS9895 and DXS6797 utilized a sample of 1193 unrelated individuals while HPRTB utilized 8767 unrelated individuals.This study significantly contributes to improving the diversity and accuracy associated with the 36 X-STR allele types.Moreover,the findings of this study provide an essential reference for calculating likelihood ratios in X-STR kinship analysis,consequently enhancing the reliability and credibility of kinship determination within the Chinese Han population.关键词
X染色体短串联重复序列(X-STR)/等位基因频率/中国汉族/荟萃分析Key words
X-STR/allele frequency/Chinese Han population/Meta-analysis分类
社会科学引用本文复制引用
张俊涛,杨幸怡,陈晓晖,徐曲毅,韩晓龙,刘超..36个X-STR基因座在汉族人群中的遗传多态性荟萃分析[J].刑事技术,2024,49(3):279-283,5.基金项目
广州市科技计划项目(201707010486) （201707010486）
广东省刑事技术"双十计划"(2022GDSSGG18) （2022GDSSGG18）
