新医学2024，Vol.55Issue(5)：335-341,7.DOI:10.3969/j.issn.0253-9802.2024.05.003
艾司氯胺酮联合右美托咪定及利多卡因麻醉诱导抑制气管插管反应
Esketamine combined with dexmedetomidine and lidocaine induced inbition of tracheal intubation response
摘要
Abstract
Objective To investigate the median effective dose(ED50)of esketamine for inhibiting tracheal intubation response during the induction of dexmedetomidine combined with lidocaine under opioid-free anesthesia(OFA).Methods Adult patients aged 18-59 years with body mass index(BMI)<30 kg/m² and ASA grade Ⅰ or Ⅱ were selected for endotracheal intubation general anesthesia.Dixon sequential method was adopted.The initial dose of esketamine was 0.5 mg/kg,and the dose of the next patient was determined according to the tracheal intubation response.The ratio of adjacent doses was 1∶1.1.The ED50 and 95%confidence interval(CI)of esketamine for inhibiting tracheal intubation response during the induction of dexmedetomidine combined with lidocaine OFA were calculated.Results A total of 29 patients were included for statistical analysis.Tracheal intubation reaction was positive in 15 cases(positive group)and negative in 14 cases(negative group).In the positive group,3 cases had cough reaction during tracheal intubation.The ED50 of esketamine for inhibiting tracheal intubation response during the induction of dexmedetomidine combined with lidocaine OFA was 0.448 mg/kg,and the corresponding 95%CI was 0.421-0.476 mg/kg.Conclusion In the OFA of esketamine combined with dexmedetomidine and lidocaine,0.448 mg/kg of esketamine results in 50%of the maximum response intensity for inhibiting tracheal intubation response.关键词
艾司氯胺酮/无阿片化麻醉/气管插管/半数有效剂量/序贯法Key words
Esketamine/Opioid-free anesthesia/Tracheal intubation/Median effective dose/Sequential method引用本文复制引用
邓东香,吴多志..艾司氯胺酮联合右美托咪定及利多卡因麻醉诱导抑制气管插管反应[J].新医学,2024,55(5):335-341,7.基金项目
海南省重点研发计划项目(ZDYF2021SHFZ087) （ZDYF2021SHFZ087）
