新医学2024，Vol.55Issue(5)：381-386,6.DOI:10.3969/j.issn.0253-9802.2024.05.010
铁死亡抑制蛋白1在肿瘤中的作用
The role of ferroptosis suppressor protein 1 in tumors
摘要
Abstract
Ferroptosis suppressor protein 1(FSP1)is a key suppressor in the process of ferroptosis,which can prevent cell death and has important biological functions and potential value in clinical application.In this article,the discovery background,gene localization and structural characteristics of FSP1,as well as its dual role in inhibiting ferroptosis and promoting apoptosis were explicitly discussed.In clinical researches,FSP1 inhibitors,such as iFSP1 and icFSP1,have been developed.Subsequently,the regulatory mechanisms of FSP1 expression,its association with tumor immune escape,and its potential as a monitoring indicator for tumor prognosis and therapeutic response will be investigated.关键词
铁死亡/铁死亡抑制蛋白1/肿瘤/铁死亡抑制蛋白1抑制剂/相分离诱导型铁死亡抑制蛋白1抑制剂Key words
Ferroptosis/Ferroptosis suppressor protein 1/Tumor/iFSP1/icFSP1引用本文复制引用
李寒童,李悦凡,周妍,王琳..铁死亡抑制蛋白1在肿瘤中的作用[J].新医学,2024,55(5):381-386,6.基金项目
2023年国家级大学生创新创业训练计划项目(202311840029) （202311840029）
