中国医疗设备2024，Vol.39Issue(6)：43-48,6.DOI:10.3969/j.issn.1674-1633.2024.06.007
常规正电子放射性核素的核纯度检测质控方法探究
Exploration of Quality Control Methods for Nuclear Purity Detection of Conventional Positron Radionuclides
摘要
Abstract
Objective To explore the application of half-life assay in the purity determination and analysis of medical positron nuclides(18F,11C,13N).Methods A cyclotron was used to accelerate proton bombardment of heavy oxygen water,nitrogen oxygen mixture,and ethanol(20 mmol/L)target water,respectively,to produce aqueous solutions of 18F,11C,and 13N positron nuclide samples.The radioactivity of the sample aqueous solution was measured every 10,2,and 2 min for 18F,11C,and 13N nuclides,and the number of radioactivity measurements was 5.According to the linear fitting formula of radioactive nuclide decay,the half-life T1/2 of the nuclide was calculated.The radionuclide purity of the sample was determined by γ-energy spectrometer.Results The results showed that the half-lives of three positron nuclides calculated by the half life measurement method was similar to that of the γ-spectrometer method,and the half-lives of radioactive nuclides in 18F,11C,and 13N samples were(110.07±0.53),(19.62±0.77),and(10.02±0.94)min,respectively,calculated using the half-life measurement method.The purity of 18F,11C,and 13N nuclides in the corresponding samples determined by the energy spectrometer was 100%,and their physical half-lives were 109.77,20.39,and 9.97 min.Conclusion The half-life determination method has the feasibility of determining the purity of medical radioactive nuclides,which is worth promoting and applying.关键词
正电子核素/放射性核素/半衰期测定法/核纯度检测Key words
positron nuclide/radionuclides/half-life measurement method/nuclear purity detection分类
医药卫生引用本文复制引用
廖光星,李宁,杨鸿宇,杨志,肖国有,何正中..常规正电子放射性核素的核纯度检测质控方法探究[J].中国医疗设备,2024,39(6):43-48,6.基金项目
广西重点研发计划(桂科AB19110015) （桂科AB19110015）
2023年度广西医科大学青年科学基金资助项目(GXMUYSF202356) （GXMUYSF202356）
广西生物靶向诊治研究重点实验室开放课题(GXSWBX202203 （）
GXSWBX202204 （）
GXSWBX202205) （）
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190559 （）
Z-A20220680 （）
Z-A20220678 （）
Z-A20220711). （）
