中国医疗设备2024，Vol.39Issue(6)：124-130,155,8.DOI:10.3969/j.issn.1674-1633.2024.06.020
DWI、DCE联合APT成像在鉴别乳腺良恶性病变中的价值研究
Value of DWI,DCE and APT Imaging in Identifying Benign and Malignant Breast Lesions
摘要
Abstract
Objective To compare the value of magnetic resonance amide proton transfer(APT)imaging,diffusion weighted imaging(DWI),dynamic contrast-enhanced(DCE)imaging and used in combination in the identification of benign and malignant breast lesions.Methods A total of 55 patients with breast disease were included,APT,DWI and DCE scans were performed to measure the magnetization transfer asymmetry(MTRasym)rate and apparent diffusion coefficient(ADC)values,and then the classification of breast imaging reporting and data system were recorded.The differences between the parameters of benign and malignant breast lesions were analyzed,the combined diagnostic model was established by Logistic regression,and the receiver operating characteristic(ROC)curve was used to calculate the diagnostic value of various diagnosis model in benign and malignant breast lesions,and the differences between different pathological factors in malignant lesions and the correlation between the pathological factors and APT were compared.Results The MTRasym and ADC values in the breast malignant group were smaller than those in the benign group,and the difference was statistically significant(all P＜0.05),and the area under curve(AUC)of DWI,APT,DCE and APT+DCE,APT+DWI,DCE+DWI,DWI+APT+DCE were 0.804,0.723,0.741 and 0.782,0.895,0.897,0.970,respectively;the AUC of DWI+APT+DCE was significantly greater than DWI,APT,DCE and any two combined diagnosis models(all P＜0.05).The MTRasym value in the Ki-67 high expression group was higher than that in the low expression group[(3.934%±0.883%)vs.(3.192%±0.949%)].The MTRasym value of the breast cancer infiltration degree histological grading Ⅲ group is higher than that of the Ⅱ group[(4.225%±0.932%)vs.(3.451%±0.873%)],and APT was moderately positive with both(r=0.627,0.537,both P＜0.05).Conclusion APT imaging has good diagnostic value in the identification of benign and malignant breast lesions,with no significant difference from conventional DWI and DCE imaging,and the diagnostic value of the combination of the three is higher.关键词
乳腺良恶性病变/酰胺质子转移成像/扩散加权成像/动态对比增强/磁共振成像Key words
benign and malignant breast lesions/amide proton transfer imaging/diffusion weighted imaging/dynamic contrast-enhanced/MRI分类
医药卫生引用本文复制引用
赵傲,武新英,付彤,王培炎,李可,申璐璐,林海,刘林栋..DWI、DCE联合APT成像在鉴别乳腺良恶性病变中的价值研究[J].中国医疗设备,2024,39(6):124-130,155,8.基金项目
南京市科技计划项目(202002056). （202002056）
