医学信息2024，Vol.37Issue(11)：29-35,7.DOI:10.3969/j.issn.1006-1959.2024.11.005
脑肿瘤患者并发静脉血栓栓塞症危险因素的Meta分析
Meta-analysis of Risk Factors for Venous Thromboembolism in Patients with Brain Tumors
摘要
Abstract
Objective To summarize the risk factors of venous thromboembolism in patients with brain tumors,so that clinical medical staff can identify the risk population of the disease as early as possible,and provide evidence-based medical basis for timely intervention.Methods The Cochrane Library,PubMed,EMbase,Web of Science,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang,and Weipu Biomedical Database were searched by computer to collect studies on venous thromboembolism in patients with brain tumors from the establishment of the database to July 31,2022.Data extraction and quality evaluation were performed on the literature,and Meta-analysis was performed using RevMan 5.3 soft ware.Results A total of 19 articles were included,and 33 risk factors were extracted.The results of Meta-analysis showed that advanced age[OR=1.44,95％CI(1.31,1.59),P＜0.000 01],advanced glioma[OR=1.74,95％CI(1.47,2.06),P＜0.000 01],motor dysfunction[OR=1.92,95％CI(1.17,3.16),P=0.01],body mass index[OR=1.13,95％CI(1.05,1.23),P=0.002],operation time＞4 h[OR=1.66,95％CI(1.46,1.89),P＜0.000 01],postoperative infection[OR=7.87,95％CI(3.95,15.66),P＜0.000 01],ventilator dependence[OR=2.76,95％CI(1.79,4.25),P＜0.000 01],D-dimer＞0.5 mg/L[OR=1.87,95％CI(1.43,2.45),P＜0.000 01],intraoperative blood loss[OR=5.49,95％CI(1.69,17.86),P=0.005]were risk factors for venous thromboembolism.Conclusion The existing evidence shows that the occurrence of venous thromboembolism in patients with brain tumors is related to many factors such as advanced age,advanced glioma,motor dysfunction,body mass index,operation time＞4 h,postoperative infection,ventilator dependence,D-dimer＞0.5 mg/L,and more bleeding.It is suggested that medical staff should identify relevant risk factors in clinical work and take preventive measures to reduce the risk of thrombosis.关键词
脑肿瘤/静脉血栓栓塞症/危险因素/循证医学Key words
Brain tuomor/Venous thromboembolism/Risk factors/Evidence medicine分类
医药卫生引用本文复制引用
张成欢,张庆庆,韩小云,林源..脑肿瘤患者并发静脉血栓栓塞症危险因素的Meta分析[J].医学信息,2024,37(11):29-35,7.基金项目
常州市第一人民医院科技项目(编号:yy2020009) （编号:yy2020009）
