初诊双相障碍Ⅱ型抑郁发作患者认知功能改变及与临床特征的关系研究OA

Objective To investigate the changes of cognitive function in patients with newly diagnosed bipolar disorder type Ⅱ depressive episode and its relationship with clinical characteristics.Methods From January 2018 to January 2021,172 patients with newly diagnosed bipolar disorder type Ⅱ depressive episode and 172 healthy people who were recruited in the physical examination center of our hospital during the same period were included.The general data,clinical characteristics,MATRICS Consensus Cognitive Battery(MCCB)and the incidence of cognitive impairment were compared between the two groups,and the correlation between clinical symptoms and cognitive function was further evaluated.Results There was no significant difference in gender,age and years of education between the two groups(P＞0.05).The total score of HAMD24 scale in the observation group was higher than that in the control group(P＜0.05).The information processing score,attention alertness score,working memory score,word learning score,visual learning score,reasoning and problem solving score,social cognitive score and MCCB total score of the observation group were lower than those of the control group(P＜0.05).The proportion of MCCB scale scores lower than 1,1.5 and 2 standard deviations in the observation group was higher than that in the control group(P＜0.05).The results of correlation analysis showed that the scores of patients'word learning ability,reasoning and problem solving ability were negatively correlated with the number of depressive episodes(P＜0.05).There was no correlation between age,years of education,number of episodes,total course of disease and HAMD24 total score and MCCB scale score(P＞0.05).Conclusion The changes of cognitive function in patients with newly diagnosed bipolar disorder type Ⅱ depressive episode are closely related to the number of depressive episodes.