阿仑膦酸钠维D3片对骨质疏松合并股骨颈骨折患者髋关节置换术后假体周围骨密度及骨代谢指标的影响OA

Objective To investigate the effects of alendronate sodium and vitamin D3 tablets on periprosthetic bone mineral density and bone metabolism indexes in patients with osteoporosis and femoral neck fracture after hip replacement.Methods A total of 50 patients with osteoporosis complicated with femoral neck fracture admitted to Suining Hospital of Traditional Chinese Medicine Affiliated to North Sichuan Medical College from March 2021 to November 2022 were selected as the research objects.They were divided into experimental group and control group by random number table method,with 25 patients in each group.The control group was treated with calcium carbonate D3 tablets after operation,and the experimental group was treated with alendronate sodium vitamin D3 tablets on the basis of the control group.The femoral trochanter bone mineral density,serum osteocalcin,procollagen type Ⅰ N-terminal propeptide,bone-specific alkaline phosphatase levels and incidence of adverse reactions were compared between the two groups.Results The bone mineral density of femoral trochanter in the experimental group was higher than that in the control group at 6 months after treatment(P＜0.05).The levels of serum osteocalcin,type Ⅰ procollagen N-terminal propeptide and serum bone-specific alkaline phosphatase in the experimental group were lower than those in the control group at 6 months after treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Alendronate sodium and vitamin D3 tablets can regulate bone metabolism,effectively prevent periprosthetic bone loss in patients undergoing hip replacement due to prevention of osteoporotic femoral neck fracture,and have high application safety.