诊断学理论与实践2024，Vol.23Issue(1)：16-22,7.DOI:10.16150/j.1671-2870.2024.01.003
慢性戊型肝炎的诊治进展
Advances in the diagnosis and treatment of chronic hepatitis E
摘要
Abstract
According to the World Health Organization,hepatitis E virus(HEV)may cause approximately 20 mil-lion new infections annually in the world,and potentially lead to more than 3 million cases of acute hepatitis.Prevalence of viral hepatitis E is high in China,and the number of newly-diagnosed hepatitis E cases has exceeded that of newly-diag-nosed hepatitis A cases.The reported incidence rate of hepatitis E increased from 1.77/100 000 in 2010 to 2.02/100 000 in 2019.HEV infections in China are mainly due to foodborne infections.Chronic HEV infection is defined as the detection of HEV RNA in blood or stools for more than 3 months.It often occurs in immunocompromised populations and may lead to rapid progression of liver fibrosis and cirrhosis in patients.In China,HEV genotype 4 is the predominant genotype,so chronic hepatitis E patients in China are also mainly infected with HEV genotype 4.The diagnosis of HEV infection is mainly based on specific HEV antibodies or pathogenic indicators.HEV infection screening should focus on patients with underlying liver diseases,women of childbearing age and the elderly,as well as immunocompromised patients(such as organ transplant patients,patients with blood tumor,HIV-infected individuals),etc.There are still many problems in the diagnosis and treatment of HEV,including the unclear risk factors for rapid progression of liver fibrosis in patients with chronic hepa-titis E,and the unclear mechanisms on that elderly men and pregnant women are prone to severe cases of HEV infection.The screening of anti-HEV drugs is mostly based on in vitro cell models,which are still in the pre-clinical stage.In the future,research should focus on the pathogenesis of hepatitis E,promoting intersection,integration,and transformation of basic re-search and clinical research,which may provide impetus for the better diagnosis and treatment of chronic hepatitis E.关键词
戊型肝炎病毒/慢性戊型肝炎/基因4型Key words
Hepatitis E virus/Chronic hepatitis E/HEV genotype 4分类
医药卫生引用本文复制引用
卢捷,谢青..慢性戊型肝炎的诊治进展[J].诊断学理论与实践,2024,23(1):16-22,7.基金项目
上海市临床重点专科资助项目(shslczdzk01103) （shslczdzk01103）
国家自然科学基金面上项目(82270618) （82270618）
