中国病理生理杂志2024，Vol.40Issue(5)：917-923,7.DOI:10.3969/j.issn.1000-4718.2024.00.008
m6A修饰在非小细胞肺癌中作用的研究进展
Progress in role of m6A modification in non-small-cell lung cancer
摘要
Abstract
N6-methyladenosine(m6A)denotes the addition of a methyl group to the sixth nitrogen atom of ade-nosine,a common occurrence in eukaryotic RNA.The m6A modifications govern RNA splicing,translocation,stability,and translation into proteins.The RNA methyltransferases,like methyltransferase-like protein 3(METTL3),METTL14,and Wilms'tumor 1-associated protein(WTAP),are responsible for these modifications,while the removal process in-volves demethylases,specifically fat mass and obesity-associated protein(FTO)and ALKB homolog 5(ALKBH5).Recog-nition of these modifications is facilitated by m6A-binding proteins,such as YTH family proteins and insulin-like growth factor 2 mRNA-binding proteins(IGF2BPs).The m6A modification regulators are involved in the onset and progression of non-small-cell lung cancer through multiple mechanisms.This review concentrates on the biological functions and molecu-lar mechanisms of m6A modification-related regulatory factors in the malignant progression of non-small-cell lung cancer.关键词
非小细胞肺癌/m6A修饰/甲基转移酶/去甲基化酶Key words
non-small-cell lung cancer/m6A modification/methyltransferases/demethylases分类
医药卫生引用本文复制引用
张乃祥,林江霞,彭金芝,曾俊伟,陈远寿,金寰..m6A修饰在非小细胞肺癌中作用的研究进展[J].中国病理生理杂志,2024,40(5):917-923,7.基金项目
国家自然科学基金资助项目(No.81960510) （No.81960510）
遵义医科大学2018年度学术新苗培养及创新探索专项项目(黔科合平台人才[2018]5772-009号) （黔科合平台人才[2018]5772-009号）
