中国病理生理杂志2024，Vol.40Issue(5)：944-949,6.DOI:10.3969/j.issn.1000-4718.2024.05.021
5-羟色胺系统在应激损伤海马神经发生中的作用
Roles of serotonin system in stress-induced impairment of hippocampal neurogenesis
摘要
Abstract
Stress is a common risk factor for emotional and cognitive dysfunction during mammalian growth and development.The hippocampal neurogenesis,which regulates the stress response,is highly susceptible to stress stimu-li.This review focuses on the pathomechanism underlying how stress stimuli affect hippocampal neurogenesis and explores the impact of aberrant 5-hydroxytryptamine(5-HT)system,including 5-HT,5-HT receptors and 5-HT neurons,on stress-induced impairment of hippocampal neurogenesis.By summarizing existing research,we aim to provide new ideas for the treatment of post-traumatic stress disorder and depression.关键词
5-羟色胺/应激/神经发生/海马Key words
5-hydroxytryptamine/stress/neurogenesis/hippocampus分类
医药卫生引用本文复制引用
朱乐,廖疏影,曾燕,梅宇飞..5-羟色胺系统在应激损伤海马神经发生中的作用[J].中国病理生理杂志,2024,40(5):944-949,6.基金项目
国家自然科学基金资助项目(No.82201351) （No.82201351）
职业危害识别与控制湖北省重点实验室开放基金项目(No.0HIC2021Z07) （No.0HIC2021Z07）
