中国当代儿科杂志2024，Vol.26Issue(5)：469-475,7.DOI:10.7499/j.issn.1008-8830.2311060
儿童T淋巴母细胞淋巴瘤采用白血病方案治疗的预后分析
Prognostic analysis of childhood T-lymphoblastic lymphoma treated with leukemia regimen
摘要
Abstract
Objective To investigate the prognosis of childhood T-lymphoblastic lymphoma(T-LBL)treated with acute lymphoblastic leukemia(ALL)regimen and related influencing factors.Methods A retrospective analysis was performed for the prognostic characteristics of 29 children with T-LBL who were treated with ALL regimen(ALL-2009 or CCCG-ALL-2015 regimen)from May 2010 to May 2022.Results The 29 children with T-LBL had a 5-year overall survival(OS)rate of 84％±7％and an event-free survival(EFS)rate of 81％±8％.The children with B systemic symptoms(unexplained fever＞38° C for more than 3 days;night sweats;weight loss＞10％within 6 months)at initial diagnosis had a lower 5-year EFS rate compared to the children without B symptoms(P＜0.05).The children with platelet count＞400x109/L and involvement of both mediastinum and lymph nodes at initial diagnosis had lower 5-year OS rates(P＜0.05).There were no significant differences in 5-year OS and EFS rates between the children treated with CCCG-ALL-2015 regimen and those treated with ALL-2009 regimen(P＞0.05).Compared with the ALL-2009 regimen,the CCCG-ALL-2015 regimen reduced the frequency of high-dose methotrexate chemotherapy and the incidence rate of severe infections(P＜0.05).Conclusions The ALL regimen is safe and effective in children with T-LBL.Children with B systemic symptoms,platelet count＞400x109/L,and involvement of both mediastinum and lymph nodes at initial diagnosis tend to have a poor prognosis.Reduction in the frequency of high-dose methotrexate chemotherapy can reduce the incidence rate of severe infections,but it does not affect prognosis.关键词
T淋巴母细胞淋巴瘤/治疗/预后/儿童Key words
T-lymphoblastic lymphoma/Treatment/Prognosis/Child引用本文复制引用
后书敏,邵静波,李红,张娜,朱嘉莳,王丹,付盼..儿童T淋巴母细胞淋巴瘤采用白血病方案治疗的预后分析[J].中国当代儿科杂志,2024,26(5):469-475,7.基金项目
上海市科学技术委员会(23015820600) （23015820600）
上海市卫生健康委员会科研课题青年项目(20204Y0471). （20204Y0471）
