中国当代儿科杂志2024，Vol.26Issue(5)：506-511,6.DOI:10.7499/j.issn.1008-8830.2310080
以假性Bartter综合征为主要表现的囊性纤维化患儿3例并文献复习
Cystic fibrosis primarily presenting with pseudo-Bartter syndrome:a report of three cases and literature review
摘要
Abstract
Objective To summarize the clinical characteristics and genetic variations in children with cystic fibrosis(CF)primarily presenting with pseudo-Bartter syndrome(CF-PBS),with the aim to enhance understanding of this disorder.Methods A retrospective analysis was performed on the clinical data of three children who were diagnosed with CF-PBS in Hunan Children's Hospital from January 2018 to August 2023,and a literature review was performed.Results All three children had the onset of the disease in infancy.Tests after admission showed hyponatremia,hypokalemia,hypochloremia,and metabolic alkalosis,and genetic testing showed the presence of compound heterozygous mutation in the CFTR gene.All three children were diagnosed with CF.Literature review obtained 33 Chinese children with CF-PBS,with an age of onset of 1-36 months and an age of diagnosis of 3-144 months.Among these children,there were 29 children with recurrent respiratory infection or persistent pneumonia(88％),26 with malnutrition(79％),23 with developmental retardation(70％),and 18 with pancreatitis or extrapancreatic insufficiency(55％).Genetic testing showed that c.2909G＞A was the most common mutation site of the CFTR gene,with a frequency of allelic variation of 23％(15/66).Conclusions CF may have no typical respiratory symptoms in the early stage.The possibility of CF-PBS should be considered for infants with recurrent hyponatremia,hypokalemia,hypochloremia,and metabolic alkalosis,especially those with malnutrition and developmental retardation.CFTR genetic testing should be performed as soon as possible to help with the diagnosis of CF.关键词
囊性纤维化/假性Bartter综合征/CFTR基因/儿童Key words
Cystic fibrosis/Pseudo-Bartter syndrome/CFTR gene/Child引用本文复制引用
张继燕,孙林军,段效军,张子敏,肖政辉,陈艳萍,游洁玉..以假性Bartter综合征为主要表现的囊性纤维化患儿3例并文献复习[J].中国当代儿科杂志,2024,26(5):506-511,6.基金项目
儿童急救医学湖南省重点实验室(2018TP1028). （2018TP1028）
