中国当代儿科杂志2024，Vol.26Issue(5)：535-540,6.DOI:10.7499/j.issn.1008-8830.2311030
孟德尔随机化研究在孤独症谱系障碍中的研究进展
Advances in Mendelian randomization studies on autism spectrum disorder
摘要
Abstract
Autism spectrum disorder(ASD)is a pervasive neurodevelopmental disorder with onset in infancy or early childhood.Mendelian randomization(MR)is a statistical method used to infer causal relationships between exposures and outcomes.This article summarizes MR studies related to ASD.Existing research supports a causal relationship between maternal inflammatory bowel disease in children with ASD,parental education levels,screen time exposure,obesity,insomnia,serum transferrin,decreased blood selenium,abnormal signals in brain functional MRI,interleukin-6,phosphodiesterase 2A,mitogen-activated protein kinase kinase 3,mitochondrial ribosomal protein L33,serotonin,and ASD.However,it does not support a causal relationship between parental rheumatoid arthritis,systemic lupus erythematosus,neonatal jaundice in children with ASD,cytomegalovirus infection,asthma,oral ulcers,vitamin D levels,and ASD.This article reviews the etiological factors related to ASD and MR studies,aiming to explore and deepen the understanding of the pathophysiology of ASD.It provides strong statistical support for the prevention,diagnosis,and treatment of ASD,and offers new methods and strategies for the etiological analysis of complex traits.关键词
孤独症谱系障碍/孟德尔随机化/研究进展/儿童Key words
Autism spectrum disorder/Mendelian randomization/Research advance/Child引用本文复制引用
胡云扬,田耕畅,刘蒙,汪鸿..孟德尔随机化研究在孤独症谱系障碍中的研究进展[J].中国当代儿科杂志,2024,26(5):535-540,6.基金项目
湖北省医学青年拔尖人才项目(10200112027). （10200112027）
