雷卉 1何金戈 1张书 1李婷 1高媛 1刘双 1陈闯 1夏岚 1王为娜 1高文凤1
作者信息
- 1. 四川省疾病预防控制中心结核病预防控制所,成都 610041
- 折叠
摘要
Abstract
Objective:To analyze the infection patterns and drug resistance information of recurrent pulmonary tuberculosis patients,and to provide evidence for the treatment and prevention of tuberculosis.Methods:A prospective study was conducted.According to the inclusion criteria,2207 strains of culture positive from pulmonary tuberculosis patients between 2012 and 2021 were collected from three drug-resistant surveillance sites in Sichuan Province(Emeishan,Fucheng and Jiangyou).After removing 286 duplicate strains,they were compared with the"Tuberculosis Information Management System"of the Chinese Center for Disease Control and Prevention to exclude 18 patients with an onset interval of less than 12 months,and the remaining 34 patients with two or more visits were selected for strain resuscitation,DNA extraction and whole genome sequencing to analyze the tuberculosis infection patterns and drug resistance of recurrent patients.Results:A total of 22 patients with recurrent tuberculosis were included in the analysis,except for 11 patients with failure of subculture of a paired strain and 1 patient with non-tuberculous by whole genome sequencing.Among them,14 cases(63.6％)were due to relapse,13(92.9％)cases were local patients,onset interval was 18.00(13.50,24.50)months,initial infection Lineage 2,cases of drug resistance,MDR and INH resistance were 10(71.4％),6(42.9％),2(14.3％)and 5(35.7％),respectively.Acquired resistance occurred in 2 patients with relapse,and resistance to Eto disappeared in 1 patient.The remaining 8(36.4％)cases were reinfection,of which 4(4/8)were local patients,onset interval was 14.50(13.25,16.75)months,cases with initial infection Lineage 2,drug resistance,MDR and INH resistance were 4(4/8),5(5/8),3(3/8),and 5(5/8),respectively,and the drug resistance types of the two infections were different.Conclusion:As a high burden area of tuberculosis,the recurrence tuberculosis was still dominated by relapse in Sichuan Province.However,we should also focus on the serious reinfection of drug resistance,actively pay attention to the treatment of such patients,and develop individualized medication regimens to reduce the recurrence of tuberculosis.关键词
结核,肺/复发/全基因组测序/结核,抗多种药物性/流行病学研究Key words
Tuberculosis,pulmonary/Recurrence/Whole-genome sequencing/Tuberculosis,resistant to multiple drugs/Epidemiologic studies分类
医药卫生
