中国防痨杂志2024，Vol.46Issue(6)：648-653,6.DOI:10.19982/j.issn.1000-6621.20240084
QuantiFERON-TB Gold Plus与QuantiFERON-TB Gold In-Tube在骨关节结核辅助诊断中的比较研究
Comparison of QuantiFERON-TB Gold Plus with QuantiFERON-TB Gold In-Tube assay in auxiliary diagnosis of osteoarticular tuberculosis
摘要
Abstract
Objective:To assess the utility and concordance of QuantiFERON-TB Gold Plus(QFT-Plus)and QuantiFERON-TB Gold In-Tube(QFT-GIT)assays in the adjunctive diagnosis of osteoarticular tuberculosis.Methods:Between April and September 2023,88 patients diagnosed with osteoarticular tuberculosis at the Beijing Chest Hospital,affiliated with Capital Medical University,were enrolled as the observation group,while 123 individuals presenting with non-tuberculous osteoarticular conditions comprised the control group.Each participant underwent concurrent peripheral blood assays using both the QFT-Plus and QFT-GIT.This study evaluated the diagnostic utility and result concordance of the two tests in aiding the diagnosis of osteoarticular tuberculosis.Results:Of the 211 initial participants,4 were excluded due to indeterminate results,leaving 207 subjects for analysis(86 in the observation group and 121 in the control).The QFT-Plus assay demonstrated a sensitivity of 95.3％(95％CI:87.9％-98.5％),specificity of 70.2％(95％CI:61.2％-78.0％),positive predictive value of 65.5％(95％CI:60.2％-77.5％),and negative predictive value of 95.5％(95％CI:88.3％-98.6％).The QFT-GIT assay recorded a sensitivity of 91.9％(95％CI:83.4％-96.4％),specificity of 66.9％(95％CI:57.7％-75.1％),positive predictive value of 66.4％(95％CI:57.1％-74.6％),and negative predictive value of 92.0％(95％CI:83.8％-96.5％).The overall concordance between QFT-Plus and QFT-GIT results was 91.8％(95％CI:88.1％-95.5％),with a positive agreement of 92.4％(95％CI:87.7％-97.2％)and a negative agreement of 90.9％(95％CI:84.9％-96.9％).The Kappa coefficient for agreement was 0.832(95％CI:0.756-0.908,P＜0.001).Conclusion:The QFT-Plus and QFT-GIT assays demonstrated substantial concordance and comparable diagnostic efficacy in the auxiliary evaluation of osteoarticular tuberculosis.关键词
结核,骨关节/诊断,鉴别/免疫学试验/评价研究Key words
Tuberculosis,osteoarticular/Diagnosis,differential/Immunologic tests/Evaluation studies分类
医药卫生引用本文复制引用
贾红彦,李自慧,潘丽萍,范俊,孙琦,宋瑞雪,杜博平,董静,王颖超,邢爱英,朱传智..QuantiFERON-TB Gold Plus与QuantiFERON-TB Gold In-Tube在骨关节结核辅助诊断中的比较研究[J].中国防痨杂志,2024,46(6):648-653,6.基金项目
北京市自然科学基金(L234055) （L234055）
通州区科技计划项目(KJ2022CX042) （KJ2022CX042）
北京市医院管理中心青年职工创新工作室-创新梦工场(202136) （202136）
通州区运河计划人才项目(YH202001) Beijing Natural Science Foundation(L234055) （YH202001）
Tongzhou Science and Technology Project(KJ2022CX042) （KJ2022CX042）
Beijing Hospitals Authority Innovation Studio of Young Staff Funding Support(202136) （202136）
Tongzhou Yunhe Project(YH202001) （YH202001）
