中国防痨杂志2024，Vol.46Issue(6)：654-663,10.DOI:10.19982/j.issn.1000-6621.20240061
大气气态污染物对农村结核分枝杆菌潜伏感染者肺结核发病的影响
Impact of gaseous air pollutants on the risk of incident active pulmonary tuberculosis among rural people with latent tuberculosis infection
摘要
Abstract
Objective:To investigate the influence of primary atmospheric gaseous pollutants on the incidence of active pulmonary tuberculosis among adults in rural areas with latent tuberculosis infection(LTBI).Methods:This study utilized a multicenter,longitudinal cohort of rural residents with LTBI(LATENTTB-NSTM),spanning from 2013 to 2018,comprising 3866 participants who were monitored quarterly over five years to document new cases of active pulmonary tuberculosis.Concentrations of atmospheric gaseous pollutants such as sulfur dioxide(SO2),nitrogen dioxide(NO2),ozone(O3),and carbon monoxide(CO)were precisely matched to the residential locations and periods under review.The association between exposure levels and the emergence of active tuberculosis was analyzed using time-dependent Cox proportional hazards models,stratified by age,sex,educational attainment,family income,and lifestyle factors.Results:Among 3866 individuals diagnosed with latent tuberculosis infection,surveillance identified 58 new cases of active pulmonary tuberculosis.Incremental exposures to SO2 and CO by 10 μg/m3 and 100 μg/m3,respectively,over a six-month period were associated with a respective 81.0％(HR=1.810,95％CI:1.153-2.843)and 19.6％(HR=1.196,95％CI:1.031-1.388)increase in the risk of developing active tuberculosis.Notably,these associations appeared more pronounced among older adults and smokers,though the differences did not reach statistical significance(interaction P-values＞0.05).Conclusion:Exposure to atmospheric gaseous pollutants,particularly SO2 and CO,is associated with a heightened risk of developing active pulmonary tuberculosis among individuals with LTBI in rural settings.The management of air quality,therefore,plays a crucial role in the strategic control of tuberculosis.关键词
结核,肺/感染/空气污染物/因素分析,统计学Key words
Tuberculosis,pulmonary/Infection/Air pollutants/Factor analysis,statistical分类
医药卫生引用本文复制引用
田思帆,何勇鹏,王大宽,刘自森,闫娇霞,沈玲羽,邸元植,陈彦宵,金奇,段伟焘,高磊,郭同磊,高旭,陈晨,张彬,辛赫男,杜江,曹雪芳,冯博轩,何翼君..大气气态污染物对农村结核分枝杆菌潜伏感染者肺结核发病的影响[J].中国防痨杂志,2024,46(6):654-663,10.基金项目
国家自然科学基金(82304098 （）
42305196 （）
82373647) （）
科技基础资源调查专项(2023FY100603) National Natural Science Foundation of China(82304098 （2023FY100603）
42305196 （）
82373647) （）
Science & Technology Fundamental Resources Investigation Program(2023FY100603) （2023FY100603）
