中国临床药理学杂志2024，Vol.40Issue(11)：1658-1660,3.DOI:10.13699/j.cnki.1001-6821.2024.11.025
用于术中肿瘤检测的光学成像剂——帕叶昔宁钠
Pafolacianine,optical imaging agents for intraoperative tumor detection
王钊 1陈超阳 2魏然 2张玄龄 2胡晓娟 3周颖4
作者信息
- 1. 北京大学第一医院药剂科,北京 100034||北京大学第一医院宁夏妇女儿童医院药剂科,宁夏回族自治区银川 750001
- 2. 北京大学第一医院药剂科,北京 100034
- 3. 北京大学第一医院宁夏妇女儿童医院药剂科,宁夏回族自治区银川 750001
- 4. 北京大学第一医院药剂科,北京 100034||北京大学第一医院药物临床试验机构,北京 100034
- 折叠
摘要
Abstract
Pafolacianine is a fluorescent agent that specifically targets folate receptors,employed in the treatment of adult ovarian cancer patients to support the detection of malignant growths during surgical interventions.Pafolacianine binds to cancer cells expressing folate receptors,accumulating within folate-receptor-positive tumor tissue through receptor-mediated endocytosis.It can be excited by near-infrared fluorescence imaging,facilitating the surgical removal of tumors during procedures.This article gives an introduction to the mechanism of action,pharmacokinetics,clinical studies,and safety aspects of Pafolacianine.关键词
帕叶昔宁钠/光学成像剂/卵巢癌/肺癌Key words
pafolacianine/optical imaging agent/ovarian cancer/lung cancer分类
医药卫生引用本文复制引用
王钊,陈超阳,魏然,张玄龄,胡晓娟,周颖..用于术中肿瘤检测的光学成像剂——帕叶昔宁钠[J].中国临床药理学杂志,2024,40(11):1658-1660,3.
