中国临床药学杂志2024，Vol.33Issue(2)：125-130,6.DOI:10.19577/j.1007-4406.2024.02.008
免疫检查点抑制剂致胰腺炎的文献分析
Literature analysis of immune checkpoint inhibitor-induced pancreatitis
汪钟香 1潘瑜 1宋霞2
作者信息
- 1. 青海省人民医院药学部,西宁 810000
- 2. 兰州大学第二医院药剂科,兰州 730030
- 折叠
摘要
Abstract
AIM To analyze the patterns and characteristics of immune checkpoint inhibitor-induced pancreatitis,and to provide reference for clinical safety in medication.METHODS Case reports on immune checkpoint inhibitor-related pancreatitis published internationally from August 2015 to December 2022 were retrieved and analyzed.RESULTS A total of 25 pieces of literature involving 25 cases with a male-to-female ratio of 4∶1 were retrieved.The average age was(61.92±12.23)years old,and the onset of symptoms often occurred more than 6 weeks after immune checkpoint inhibitor treatment.Clinical manifestations primarily included abdominal pain,back pain,nausea,vomiting,diarrhea and fever.Laboratory examinations revealed elevated levels of amylase and lipase and imaging features showed diffuse pancreatic enlargement and peripancreatic fat infiltration.Among the cases,20 patients improved after treatment,4 patients died after treatment and the outcome of 1 patient was not mentioned.CONCLUSION There is a risk of mortality in pancreatitis.Therefore,vigilance and proactive management for the occurrence of pancreatitis throughout the entire course of immune checkpoint inhibitor therapy are essential.关键词
免疫检查点抑制剂/胰腺炎/药物不良反应Key words
immune checkpoint inhibitor/pancreatitis/adverse drug reaction引用本文复制引用
汪钟香,潘瑜,宋霞..免疫检查点抑制剂致胰腺炎的文献分析[J].中国临床药学杂志,2024,33(2):125-130,6.
