摘要
Abstract
Objective To investigate the aesthetic effect of botulinum toxin type A in the prevention and treatment of frontal trauma scar and its influence on serum TGF-β1 and BMP-7 levels.Methods A total of 84 patients with frontal trauma admitted to the author's hospital from July 2020 to October 2022 were selected as the research objects.According to the random number table method,they were divided into the observation group and the control group,with 42 cases in each group.The control group was treated with debridement and cosmetic suture combined with topical silicone gel preparation to prevent and treat scar.In the observation group,botulinum toxin type A was injected on both sides of the wound after the cosmetic suture was removed to prevent scar.Three months after the stitches were removed,the effective rate of clinical prevention and treatment of scar,scar score[Vancouver scar scale(VSS)],scar pain or pruritus score[visual analogue scale,VAS],patient satisfaction,serum transforming growth factor-β1(TGF-β1)level,recombinant bone morphogenetic protein 7(BMP-7)level and adverse reactions were compared between the two groups.Results The VSS score and VAS score of scar pain or pruritus in the observation group were lower than those in the control group(P＜0.05).The effective rate of clinical prevention and treatment of scar in the observation group was 90.47%,which was higher than 69.04%in the control group(P＜0.05).The satisfaction of patients in the observation group was higher than that in the control group(P＜0.05).The level of TGF-β1 in the observation group was lower than that in the control group,and the level of BMP-7 was higher than that in the control group(P＜0.05).No serious adverse reactions occurred in the two groups.Conclusion Injection of botulinum toxin type A on both sides of the wound in patients with frontal soft tissue trauma after cosmetic suture removal can inhibit scar formation,effectively improve the efficiency of scar prevention and treatment and patient satisfaction.Its clinical effect may be related to the regulation of serum TGF-β1 and BMP-7 levels,and it is safe and has certain clinical application value.关键词
A型肉毒毒素/额部外伤/瘢痕/转化生长因子β1/骨成型蛋白7Key words
botulinum toxin type A/forehead trauma/scar/transforming growth factor-β1/recombinant bone morphogenetic protein 7分类
医药卫生
