经脐单孔腹腔镜胆囊切除术对胆囊结石患者胃肠功能和血清固醇激素调节元件结合蛋白2水平的影响OACSTPCD

Objective To investigate the impacts of transumbilical single-port laparoscopic cholecystectomy(TUSPLC)on gastrointestinal function and serum sterol regulatory element-binding protein-2(SREBP-2)level in patients with cholecystolithiasis.Methods 100 patients with cholecystolithiasis from September 2021 to August 2022 were selected as the study objects,and divided them into control group and study group by random number table method,with 50 cases in each group.The control group underwent laparoscopic cholecystectomy,study group underwent TUSPLC,the efficacy of the two groups was compared.Results The intraoperative blood loss of patients treated with different treatment methods showed no difference(P>0.05).Patients treated with TUSPLC had longer operation time,and shorter hospital stay,the anal exhaust time,feeding time,bowel sound recovery time and defecation time compared with control group(P<0.05).Before operation,there were no differences in McGill Brisbane symptom score(MBSS),serum SREBP-2,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05).Three months after surgery,the MBSS,serum SREBP-2,IL-6 and TNF-α were decreased compared with before the surgery in two groups,and the change in the study group was greater compared with control group,the differences were statistically significant(P<0.05).There was no difference in the incidence of complications(P>0.05).Conclusion TUSPLC has a definite effect in the treatment of cholecystolithiasis,can reduce the levels of serum SREBP-2 and inflammatory factors in patients,and can improve the gastrointestinal function of patients with high safety.