健脾化痰方通过调控FOXO1/PDK4信号通路干预PCOS-IR大鼠脂代谢的作用机制研究OA北大核心CSTPCD
Effects of Jianpi Huatan Fang on lipid metabolism and FOXO1/PDK4 expression in the ovary in rats with polycystic ovary syndrome and insulin resistance
目的 探讨健脾化痰方对多囊卵巢综合征合并胰岛素抵抗(PCOS-IR)大鼠脂代谢及叉头盒转录因子-1(FOXO1)/丙酮酸脱氢酶激酶 4(PDK4)信号通路的影响.方法 40 只雌性SD大鼠随机分为空白对照组 10只和造模组 30 只.采用高脂饮食(8 周)联合来曲唑(第 4～8 周加入)建立PCOS-IR大鼠模型.完成造模后,将造模组大鼠随机分为模型对照组、健脾化痰方组、二甲双胍组,药物干预 4 周.观察各组一般情况,测定中医证候评分,计算体重变…查看全部>>
Objective To investigate the effects of Jianpi Huatan Fang on lipid metabolism and expression levels of FOXO1 and PDK4 in rats with polycystic ovary syndrome(PCOS)and insulin resistance(IR).Methods Forty female rats were divided randomly into a blank control group(n=10)and a model group(n=30).A PCOS-IR rat model was established using a high-fat diet(8 weeks)combined with letrozole(added at weeks 4～8).Thirty successfully modeled rats were then divided randoml…查看全部>>
杨璐瑜;林安盈;杨正望;李岚;余曦明
湖南中医药大学第一附属医院,长沙 410021湖南中医药大学,长沙 410208湖南中医药大学第一附属医院,长沙 410021湖南中医药大学第二附属医院,长沙 410005湖南中医药大学,长沙 410208
生物学
多囊卵巢综合征胰岛素抵抗脂代谢FOXO1PDK4健脾化痰方
polycystic ovary syndromeinsulin resistancelipid metabolismFOXO1PDK4Jianpi Huatan Fang
《中国实验动物学报》 2024 (4)
451-460,10
湖南省自然科学基金青年项目(2022JJ40317),湖南中医药大学中药粉体与创新药物省部共建国家重点实验室培育基地开放基金(21PTKF1011). Funded by the Hunan Natural Science Foundation Youth Program(2022JJ40317),Open Fund for the Cultivation Base of State Key Laboratory of Traditional Chinese Medicine Powder and Innovative Drugs Jointly Built by Hunan University of Chinese Medicine(21PTKF011).
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