中国实验动物学报2024，Vol.32Issue(4)：539-546,8.DOI:10.3969/j.issn.1005-4847.2024.04.015
色氨酸代谢调控肠道应激损伤作用的研究进展
Regulation of tryptophan metabolism in stress-related gastrointestinal disorders
摘要
Abstract
The intestine is the largest immune and metabolic site in the body and is thus important for animal health.The integrity of the mucosal barrier and function are fundamental factors protecting the health of the intestine.Stress has been reported to have profound effects on the gastrointestinal tract,including altering gut permeability,the intestinal barrier,and homeostasis.Tryptophan is a functional essential amino acid that alters the gut microbiota and regulates intestine structural and functional change,thus contributing to host physiology and metabolism.Changes in tryptophan metabolism and its metabolites in brain and intestinal tissues during stress suggest that tryptophan may play an important role in the stress response.We therefore review the literature on the mechanisms underlying stress-related diseases and the role of tryptophan metabolism in the regulation of gut homeostasis,with particular focus on functional bowel disorders and their relationship to stress,to provide a theoretical foundation for targeting tryptophan in stress-related intestine diseases.关键词
应激/肠道微生物/肠-脑轴/色氨酸代谢/肠应激损伤Key words
stress/gut microbiota/gut-brain axis/tryptophan metabolism/stress-related intestinal disorders分类
生物科学引用本文复制引用
陈菁青,郑建华,董巧燕,张文盛,马连素,邱业峰..色氨酸代谢调控肠道应激损伤作用的研究进展[J].中国实验动物学报,2024,32(4):539-546,8.基金项目
全军实验动物专项课题(SYDW_KY[2021]06),军事医学研究院青年人才基金项目(AMMS-QNPY-2022-019). Funded by Special Topics on Laboratory Animals in the Army(SYDW_KY[2021]06),Young Talent Programmed of the Academy of Military Medical Sciences(AMMS-QNPY-2022-019). （SYDW_KY[2021]06）
