中国实用内科杂志2024，Vol.44Issue(5)：397-402,6.DOI:10.19538/j.nk2024050109
2型糖尿病合并痛风性关节炎患者单核细胞高密度脂蛋白胆固醇比值与非酒精性脂肪肝关系研究
Correlation analysis of monocyte/high-density lipoprotein cholesterol ratio and NAFLD in patients with type 2 diabetes mellitus and gouty arthritis
摘要
Abstract
Objective To investigate the relationship between the ratio of monocyte to high-density lipoprotein cholesterol(MHR)and non-alcoholic fatty liver disease(NAFLD)in patients with type 2 diabetes mellitus(T2DM)and gouty arthritis(GA),and to analyze the influencing factors of NAFLD.Methods A total of 214 patients with T2DM and GA hospitalized in The First Clinical Medical School of Anhui University of Chinese Medicine from December 2019 to December 2022 were enrolled,who were divided into NAFLD group and non-NAFLD group according to whether they had NAFLD or not.General data and laboratory indicators of the two groups were compared.Subgroup analysis was performed in NAFLD group according to HOMA-IR level.They were divided into Qi MHR,Q2MHR and Q3MHR groups according to the MHR tertile,and the differences in HOMA-IR levels and the incidence of NAFLD among the Q1MHR,Q2MHR and Q3MH groups were compared.Logistic regression analysis was performed to analyze the risk factors of NAFLD in T2DM patients with GA,and Receiver Operating Characteristic Curve(ROC)was used to evaluate the clinical value of MHR in T2DM patients with GA.Results Compared with non-NAFLD group,Fins,HOMA-IR,AST,ALT,TG,CRP,MON and MHR in NAFLD group were increased(P＜0.05),while HDL-C decreased(P＜0.05).In NAFLD group,compared with HOMA-IR＜2.5 subgroup,BMI,WHR,FPG,SUA,TC,TG,LDL-c,CRP,MON and MHR levels in HOMA-IR≥2.5 subgroup were increased(P＜0.05).According to the MHR tertile,the level of HOMA-IR in Q3MHR[4.67(2.93,7.29)]subgroup was significantly higher than that in Q1MHR[3.44(1.85,4.89)]and Q2MHR[4.15(2.13,6.03)]subgroup(P＜0.05).The incidence of NAFLD in Q3MHR subgroup was higher than that in Q1MHR and Q2MHR subgroups(74.51％vs.23.08％,39.22％,P＜0.05)and Q2MHR subgroup was higher than Q1MHR subgroup(39.22％vs.23.08％,P＜0.05).Multivariate Logistic regression analysis showed that LDL-c,CRP and MHR were risk factors for NAFLD in T2DM patients with GA(P＜0.05).ROC curve results showed that the area under the curve(AUC)of MHR in predicting NAFLD in T2DM patients with GA was 0.759,with a sensitivity of 72.9％and a specificity of 71.4％.Conclusion MHR is correlated with the occurrence of NAFLD in patients with T2DM and GA.Moreover,MHR has some predictive value for the occurrence of NAFLD in T2DM patients with gouty arthritis.关键词
2型糖尿病/痛风性关节炎/单核细胞高密度脂蛋白胆固醇比值/非酒精性脂肪肝Key words
type 2 diabetes mellitus/gouty arthritis/monocyte/HDL cholesterol ratio/non-alcoholic fatty liver disease分类
医药卫生引用本文复制引用
石红宾,李中南,陈明月,彭甜甜,陈理,王玉..2型糖尿病合并痛风性关节炎患者单核细胞高密度脂蛋白胆固醇比值与非酒精性脂肪肝关系研究[J].中国实用内科杂志,2024,44(5):397-402,6.基金项目
国家中医临床研究基地业务建设科研专项立项课题(JDZX2012004) （JDZX2012004）
安徽省红十字会中医药传承创新发展研究项目(2022ZYZD01) （2022ZYZD01）
安徽省名中医及基层名中医工作室建设项目[中发展(2020)10号] （2020）
